Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.
Introduction: L74V, E89G, V111I, S215Y, L74V/S215Y and E89G/S215Y), whose effects were evaluated for a small subset of misincorporations or mispairs using nucleotide discrimination assays.
HIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, China.
Result: For example, M41L and D67N had 16 (D218E, E44A, G190S, G196E, H221Y, I142V, K101E, L210W, L228R, L74V, M184V, R211K, T215F, V108I, V118I, and V179I) and nine (E44A, H208Y, H221Y, K70R, L210W
Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis.
Abstract: Sub-population analysis revealed that EFV + 3TC + ddI failed patients had more DRMs compared to EFV + 3TC + ZDV failed patients, especially the ddI DRM L74IV and several additional NNRTI DRMs.
Abstract: The most common NRTI mutations were M184V (80%), L74V (31%), L74I (17%), K219E (9%), and M184I (9%), NNRTI mutations were K103N (83%), P225H (14%), L100I (11%), and Y188L (11%), reflecting generally the similar pattern of DRMs to that seen in treatment failed subtype B viruses.
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naive and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes.
Discussion: L74V was the second most frequent mutation in subjects using the alternative first line-scheme consisting of EFV + 2 NRTIs, mainly ABC (37.3%) or ddI (23.5%) or AZT (19.6%).
Discussion: Intermediate to high resistance levels to NRTIs in the ARV drug-experienced subjects were reported in Panama in previous years (2004-2005) and were associated to mutations L74V (2.4%), T215F/Y (3.6%) and M184V (1.2%).
Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses.
Discussion: L74V and M184I are associated with resistance against ABC, which is co-formulated with DTG and lamivudine in a single daily pill; these results suggest that this combination may provide an advantage in regard to pathways leading to drug resistance.
Discussion: L74V is associated with a reduced replicative capacity of HIV-1 of about 11 % compared to WT.
Discussion: Given that the R263K substitution has been reported in some INSTI-naive patients in the SAILING study and in tissue culture selections, we aimed to investigate the e
Discussion: In our study, decreased replication was also observed with the R263K-L74V virus and this was greatly exacerbated by the additional presence of H51Y.
Prevalence of Integrase Strand Transfer Inhibitors (INSTI) Resistance Mutations in Taiwan.
Method: Some amino acid substitutions (H51L/R, L74V, P145R, V151I, and S230N) that have been described in more than 2% of the study population in previous studies or this study were also included for analysis.
Result: One sequence was identified to harbour Q148R/L74V/P145R mutation, which was predicted to have medium-level resistance to dolutegravir.
From antiretroviral therapy access to provision of third line regimens: evidence of HIV Drug resistance mutations to first and second line regimens among Ugandan adults.
HIV mutation literature information.
PMID: 
2017
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