literature

HIV mutation literature information.

Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort.

PMID: 29584723 2018 PLoS medicine

Table: L74V

High prevalence of HIV-1 transmitted drug resistance among therapy-naive Burmese entering travelers at Dehong ports in Yunnan, China.

PMID: 29739342 2018 BMC infectious diseases

Result: NRTI resistance-associated mutations found in this population included M184 V (n = 3, 6.67%), M41 L (n = 2, 4.44%), T215F (n = 2, 4.44%), L74F/V (n = 2, 4.44%), D67G (n = 1, 2.22%) and K70Q (n = 1, 2.22%) (Figure1).

HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection.

PMID: 29844604 2018 Scientific reports

Discussion: Patient 91_co (HIV/HCV) has the codons T12S, L19I, L74V, K103R, E122K, D123E, I135T, S163C, M184V, L214F, K219E, E224K, V245M, L100I, V106I, V179D and M230L and used the drugs 3TC, EFV and TDF for treatment.

Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.

PMID: 30223845 2018 Virology journal

Result: The major drug resistance associated mutations to NRTIs seen among the Group 1 participants were M41 L, M184 V, M184MV, L74 V and T215Y with no minor drug resistant associated mutations to NRTIs in this group.

Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report.

PMID: 30503324 2018 The lancet. HIV

Abstract: The HIV genotype revealed Met184Val, Leu7

Result: Genotypic testing (GenoSure MG) for the HIV strain isolated from this patient showed notable RT mutations of L74V, L100I, M184V, and K103N, none of which are known to confer resistance to TDF, although M184V confers high-level resistance to FTC.

Result: SGS was consistent with the standard genotype in detecting RT mutations: specifically L74V, L100I, M184V, and K103N were detected, but K65R and K70E were not.

Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.

PMID: 28333133 2017 Scientific reports

Introduction: L74V, E89G, V111I, S215Y, L74V/S215Y and E89G/S215Y), whose effects were evaluated for a small subset of misincorporations or mispairs using nucleotide discrimination assays.

Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).

PMID: 28891788 2017 HIV clinical trials

Method: Primary NRTI-R substitutions assessed were M41L, A62V, K65R, D67N, T69 insertions, K70E/R, L74I/V, V75I, F77L, Y115F, F116Y, Q151M, M184V/I, L210W, T215F/Y, and K219E/N/Q/R in RT.

HIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, China.

PMID: 28114955 2017 AIDS research and therapy

Table: L74I/V

Table: L74V

Polymorphisms and Mutational Covariation Associated with Death in a Prospective Cohort of HIV/AIDS Patients Receiving Long-Term ART in China.

PMID: 28099515 2017 PloS one

Result: For example, M41L and D67N had 16 (D218E, E44A, G190S, G196E, H221Y, I142V, K101E, L210W, L228R, L74V, M184V, R211K, T215F, V108I, V118I, and V179I) and nine (E44A, H208Y, H221Y, K70R, L210W

Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis.

PMID: 28086929 2017 AIDS research and therapy

Table: L74V

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