Discussion: Furthermore, we found that the major NNRTI-related SDRMs were K101P, K103N, V106A, E138A, Y181C, and Y188H, and the major NRTI-related SDRMs were L74V/I and M184V.
Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.
Result: Sub-subtype A6 and other genetic variants of subtype A included L74L in 3.7% and 86.4% of cases, L74I in 94.9% and 9.6%, L74M in 1.2% and 3%, and L74V in 0.1% and 1%, respectively.
Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.
Prevalence of HIV-1 Integrase Strand Transfer Inhibitor Resistance in Treatment-Naive Voluntary Counselling and Testing Clients by Population Sequencing and Illumina Next-Generation Sequencing in Taiwan.
Result: Among the 38 patients who had both sanger sequencing and Illumina NGS data, 5% (2/38) had NRTI/NNRTI/PI resistance and none had INSTI resistance (one had an L74V substitution) by sanger sequencing however Illumina NGS for INSTI resistance detected four more INSTI resistance ( 1%) associated mutations with low frequency (G163R 3.25%, S153Y 1.36%, S153F 3.21% and Y143H 2.06%) (Table 5).
Table: L74V
Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.
PMID: 33654530
2020
The Pan African medical journal
Table: L74V
Antiretroviral drug resistance mutations among patients failing first-line treatment in Hanoi, Vietnam.
HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting.
PMID: 31117863
2019
Journal of the International Association of Providers of AIDS Care
Table: L74V
Primary HIV Drug Resistance among Recently Infected Cases of HIV in North-West India.
Abstract: Observed mutations were K219R, L74V, K219N, and Y181C.
Result: One isolate, belonging to MSM, had L74V, a NRTI resistance mutation that is known to cause Intermediate Resistance to Abacavir (ABC).
Epidemiology of human immunodeficiency virus (HIV) drug resistance in HIV patients with virologic failure of first-line therapy in the country of Georgia.
HIV mutation literature information.
PMID: 
2020
Infection and drug resistance
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