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 HIV mutation literature information.


  Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine.
 PMID: 17667333       2007       Journal of acquired immune deficiency syndromes (1999)
Abstract: Among baseline samples from 154 treatment-experienced patients, 8 had K65R and 44 had L74V/I by population sequencing.
Abstract: BACKGROUND: Prior abacavir (ABC) or didanosine (ddI) therapy can result in the L74V/I or K65R mutation in HIV-1 reverse transcriptase.
Abstract: CONCLUSIONS: Prior therapy with ABC or ddI can result in a population genotype that shows K65R or L74V/I but does not reveal low-level K65R present in some patients.


  Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance.
 PMID: 17668566       2007       Antiviral therapy
Abstract: Of the 42 aa substitutions currently associated with INI resistance, 21 occurred as natural polymorphisms: V72I, L74I, T97A, T112I, A128T, E138K, Q148H, V151I, S153Y/A, M154I, N155H, K156N, E157Q, G163R, V165I, V201I, I203M, T206S, S230N and R263K.


  Clinical utility of genotyping resistance test on determining the mutation patterns in HIV-1 CRF01_AE and subtype B patients receiving antiretroviral therapy in Hong Kong.
 PMID: 16386461       2006       Journal of clinical virology
Abstract: However, the frequencies of L74V/I and K103N in the reverse transcriptase region were different between CRF01_AE and subtype B viruses.


  Risk factors for selection of the L74I reverse transcriptase mutation in human immunodeficiency virus type 1-infected patients.
 PMID: 16801444       2006       Antimicrobial agents and chemotherapy
Abstract: L74I was strongly associated with T215F, K70R, and V75M/S/T/A mutations and increased with the number of thymidine analog mutations.
Abstract: The L74I mutation was carried by 7% of viruses.


  Identification of alternative amino acid substitutions in drug-resistant variants of the HIV-1 reverse transcriptase.
 PMID: 16847406       2006       AIDS (London, England)
Abstract: Phenotypic analysis indicated that drug-resistance properties of the alternative Y181V and L74I mutants are similar, but not identical, to that of the well-known Y181C and L74V mutations.


  Coexistence of the K65R/L74V and/or K65R/T215Y mutations on the same HIV-1 genome.
 PMID: 16931138       2006       Journal of clinical virology
Abstract: Analysis of 73 clones (patient 1: 12 clones; patient 2: 27 clones; patient 3: 13 clones; patient 4: 21 clones) showed that 29 clones harboured K65R and L74V/I mutations.
Abstract: OBJECTIVE: To determine to which extent the mutations K65R, L74V/I and T215Y/F are linked to the same HIV-1 genome.


  Differential impact of thymidine analogue mutations on emtricitabine and lamivudine susceptibility.
 PMID: 17075395       2006       Journal of acquired immune deficiency syndromes (1999)
Abstract: For samples with K65R, L74I/V, or Q151M mutations, the phenotypic impact was similar, as the mean fold-change was not significantly different between drugs.


  Early virological failure with a combination of tenofovir, didanosine and efavirenz.
 PMID: 15751775       2005       Antiviral therapy
Abstract: Additionally, L74V/I and K65R were detected in four and two patients, respectively.


  Effect of concurrent zidovudine use on the resistance pathway selected by abacavir-containing regimens.
 PMID: 15544690       2004       HIV medicine
Abstract: RESULTS: K65R was selected infrequently by ABC-containing regimens in the absence of ZDV (13 of 127 patients), while L74V/I was selected more frequently (51 of 127 patients).
Abstract: Selection of both K65R and L74V/I was significantly reduced by co-administration of ZDV with ABC (one of 86 and two of 86 patients, respectively).


  Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles.
 PMID: 11264389       2001       Journal of virology
Abstract: The combination of both mutations with an L74I change (Delta67+T69G/L74I) leads to a novel 3'-azido-3'-deoxythymidine resistance motif and compensates for impaired HIV replication.



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