literature

HIV mutation literature information.

Lack of resistance to integrase inhibitors among antiretroviral-naive subjects with primary HIV-1 infection, 2007-2013.

PMID: 24831260 2015 Antiviral therapy

Result: Viral polymorphisms in integrase were identified in 24 (28%) subjects, including V54I (n=1), L74I (n=7), V151I (n=3) M154I (n=2), M154L (n=2), G163E (n=1), I203M (n=2), and S230N (n=6).

Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.

PMID: 25674767 2015 Viruses

Abstract: A major drug resistant mutation in RT gene, L74I (NRTI), and two such mutations, K101E and G190A (NNRTI), were obse

Result: A salient observation of the study is the presence of the L74I mutation, which confers high level of resistance to didanosine, in a drug naive patient (AIIMSU63).

Table: L74I

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.

PMID: 25849352 2015 PLoS medicine

Result: L74I (4.4%; eight of 184), V75M (8.2%; 15 of 184), and M184I (3.8%; seven of 184) accounted for a higher proportion of the NRTI SDRMs in SSEA than in other regions (<2% for each mutation in each of the other regions; p < 0.001).

HIV-1 diversity in an antiretroviral treatment naive cohort from Bushbuckridge, Mpumalanga Province, South Africa.

PMID: 25889106 2015 Virology journal

Result: L74I is an accessory mutation for integrase.

Table: L74I

Influence of Drug Resistance Mutations on the Activity of HIV-1 Subtypes A and B Integrases: a Comparative Study.

PMID: 25927004 2015 Acta naturae

Introduction: Secondary and tertiary mutations (G140A/C/S, L74I and E138A/K/T) further enhance the resistance.

Integrase inhibitor (INI) genotypic resistance in treatment-naive and raltegravir-experienced patients infected with diverse HIV-1 clades.

PMID: 26311843 2015 The Journal of antimicrobial chemotherapy

Method: Dolutegravir resistance categories were as follows: (i) no resistance, absence of Q148H/R/K; (ii) low-level resistance, Q148H/R/K in the absence of G140S/A/C, L74I and E138A/K/T; (iii) intermediate-level resistance, Q148H/R/K with one of the mutations G140S/A/C, L74I or E138A/K/T; and (iv) high-level resistance, Q148H/R/K with two or three of the mutations G140S/A/C, L74I and E138A/K/T.

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Result: Mutations M41L (above) and L74I/V (below) were outside the CI for Portugal but not for DE, and T69N (above) and K65R (below) were outside the CI for DE but not for Portugal.

Discussion: We show here that D30N, N88D/S and L90 M also have high transmissibility and that other SDRMs have higher (M41L, T215Rev and K219E/N/Q/R for NRTIs and K101E/P for the NNRTIs) or lower transmissibility (K70E/R, L74I/V, and T215Y/F f

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Table: L74I

Outcome of patients on second line antiretroviral therapy under programmatic condition in India.

PMID: 26572102 2015 BMC infectious diseases

Table: L74I

Lack of integrase inhibitors associated resistance mutations among HIV-1C isolates.

PMID: 26626277 2015 Journal of translational medicine

Discussion: The occurrences of polymorphic minor INI-accessory mutations (L74I, T125A, V165I, T206S, L234I and V201I) are similar to previous HIV-1C isolates from South Africa.

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