literature

HIV mutation literature information.

HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar.

PMID: 32368103 2020 Infection and drug resistance

Discussion: Furthermore, we found that the major NNRTI-related SDRMs were K101P, K103N, V106A, E138A, Y181C, and Y188H, and the major NRTI-related SDRMs were L74V/I and M184V.

HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016.

PMID: 32280691 2020 BioMed research international

Result: The most commonly observed mutations with NRTIs were M184I/V (59.59%, 146/245), K65R (28.16%, 69/245), D67N/G (19.18%, 47/245), K70E/K/R (17.14%, 42/245), Y115F (15.10%, 37/245), L74I/V (11.02%, 27/245), and T215I/Y (8.16%, 20/245).

Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.

PMID: 32576136 2020 BMC infectious diseases

Figure: Note: PIs mutations: M46I, I54V, V82A, K20T, L10F/LFI and Q58E/QE; NRTIs mutations: D67N/DN, K70R/KR/T, M184V/MV/I, T215F/FS/TNSY, K219Q, K65R, L74I/LI/LV, Y115F, L210W, M41L and V75I; NNRTIs mutation:

PMID: 31024744 2019 Acta naturae

Result: The mutation L74I specific to IN_A was found only in 4% of the sequences of CRF63_02A1 IN.

High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO.

PMID: 30891603 2019 The Journal of antimicrobial chemotherapy

Result: Another HIV-1 strain displayed the accessory mutations G140R and L74I, and three APOBEC-related mutations:

Discussion: Along with the DRMs displayed at codon 138, the polymorphic accessory mutations G140K, G140R, G163R and L74I (5.5% for each) in the IN gene were also observed in our study.

Discussion: Although L74I and G163R are usually selected by INSTI drugs, they have also been reported in INSTI-naive patients at rates similar to those reported in the present study; alone, they do not appear to be associated with reduced INSTI susceptibility.

Absence of Integrase Strand Transfer Inhibitor Associated Resistance in Antiretroviral Therapy Naive and Experienced Individuals from Western India.

PMID: 30793915 2019 AIDS research and human retroviruses

Abstract: Other accessory mutations were L74IM (34.48%), Q95K (1.72%), and T97A (1.72%).

HIV-1 drug resistance testing is essential for heavily-treated patients switching from first- to second-line regimens in resource-limited settings: evidence from routine clinical practice in Cameroon.

PMID: 30871487 2019 BMC infectious diseases

Result: Of note, L74I (following exposure to TDF-containing regimens) and L210 W (following exposure to regimens containing a thymidine analogue) mutations were found only in the group of patients infected with CRF02_AG viruses.

Discussion: Even though the analysis of CRF02_AG versus non-AG showed no major effect of the local subtype distribution on emerging DRMs, molecular epidemiology surveillance merits further investigations, which include the preferential pattern of L74I as a potential signature in CRF02_AG-infected patients.

Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population.

PMID: 29846534 2019 Clinical infectious diseases

Result: The non-TAMs K65R, L74V/I, Y115F, and Q151M each occurred in just 1 or 2 individuals.

Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.

PMID: 30650082 2019 PloS one

Result: A Kaplan-Meier analysis could be performed for 18 TDRMs (K20T, L23I, K43T, M46I/L/V, I54V, M41L, L74I, M184V, L210W, K219R, T215A/C/D/N/S and T215Y).

Discussion: In contrast, the mean survival times determined for NRTI mutations T215Y/A/N and L74I, which were also found at a lower proportion among the transmitted NRTI mutations, ranged from 1.0 to 1.7 years.

Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.

PMID: 30380053 2019 The Journal of antimicrobial chemotherapy

Result: Fifteen participants had integrase DRM20% (15/83, 18.1%), including Q148R conferring low-level resistance to dolutegravir, and some accessory integrase mutations were also found: L74I/M (n = 12/15, 80.0%), E157Q (n = 1) and G163R (n = 1).

Result: While no major mutation was described for dolutegravir resistance, we found some accessory integrase mutations in 98/524 (18.7%), such as L74I/M (n = 81/98, 82.7%), T97A (n = 8/98, 8.2%) and E157Q (n = 5/98, 5.1%), and more sporadically E138D/K (n = 2), V151I (n = 1) and G163R

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