Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon.
PMID: 18507527
2008
AIDS research and human retroviruses
Abstract: Other mutations frequently detected were K20I, L63P, H69K, and I13V.
Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation.
PMID: 18545158
2008
Journal of acquired immune deficiency syndromes (1999)
Abstract: These simulations documented that the G48E mutant interacted with PI resistance mutations (M46I, I54V, Q58E, and L63P) and with natural polymorphisms specific to subtype A1 (E35D, M36I, and R57K) that were present in the patient's virus.
Prevalence of drug resistance and associated mutations in HIV-positive Puerto Ricans: sex variations.
Abstract: The most prevalent mutations in the protease gene were L63P, M361, L90M, A71V, and L101.
Genotypic resistance analysis of the virological response to fosamprenavir-ritonavir in protease inhibitor-experienced patients in CONTEXT and TRIAD clinical trials.
PMID: 18852278
2008
Antimicrobial agents and chemotherapy
Abstract: The JT procedure led to selecting the CONTEXT/TRIAD genotypic set of mutations, I15V, M46I/L, I54L/M/V, D60E, L63P/T, and I84V, as providing the strongest association with the VR (P = 1.45 x 10(-11)).
[Study on the drug resistance situation among recently infected HIV-1 patients in Dehong].
PMID: 19173856
2008
Zhonghua liu xing bing xue za zhi
Abstract: Minor mutation in PR region such as M361/V, L63P and H69K appeared frequently and the rates were 81.25%, 70.31% and 65.63% respectively.
Interpretation of genotype and pharmacokinetics for resistance to fosamprenavir-ritonavir-based regimens in antiretroviral-experienced patients.
PMID: 17296739
2007
Antimicrobial agents and chemotherapy
Abstract: The Zephir mutation score included 12 IAS protease mutations associated with poorer virological response: L10I/F/R/V, L33F, M36I, M46I/L, I54L/M/T/V, I62V, L63P, A71I/L/V/T, G73A/C/F/T, V82A/F/S/T, I84V, L90M, and polymorphism mutations I13V, L19I, K55R, and L89M.
Genotypic resistance mutations to antiretroviral drugs in treatment-naive HIV/AIDS patients living in Liaoning Province, China: baseline prevalence and subtype-specific difference.
PMID: 17411368
2007
AIDS research and human retroviruses
Abstract: The frequencies of minor mutations to protease inhibitors (PI) were I93L (71.4%), L63P (62.6%), V77I (62.6%), M36I/V (33.0%), A71T/V (22.0%), K20R (6.6%), G16E (6.6%), and L10I (5.5%).
HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
Result: In contrast, the accessory mutation L63P preceded L90M in 160 of 172 persons, and the accessory mutations L10I and A71V preceded the major mutation I84V in 51 of 59 and 35 of 38 persons, respectively.
Polymorphisms and drug resistance analysis of HIV-1 CRF01_AE strains circulating in Fujian Province, China.
Abstract: The proportion of substitutions L63P, A71T/V, V77I and I93L in subtype B' sequences was considerably higher than in CRF01_AE viruses, while the proportion of L10I, M36I and K20R/I substitutions in subtype B' sequences was relatively lower than in CRF01_AE strains.
Conformational flexibility in the flap domains of ligand-free HIV protease.
Abstract: The mutant HIV PR, which evolved in response to treatment with the potent inhibitor TL-3, contains six point mutations relative to the wild-type enzyme (L24I, M46I, F53L, L63P, V77I, V82A).
HIV mutation literature information.
PMID: 
2008
AIDS research and human retroviruses
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