Result: It must be noted, that three of the patients with developed drug resistance were heavily experienced with reverse transcriptase (RT) and protease (PR) mutations (patient 1: RT: M41L, K103N, M184V, T215S; PR: L10I; patient 2: PR: M41L, V118I, K103N, M184V, L210W, T215S, RT: L10I,
Monitoring HIV viral load in resource limited settings: still a matter of debate?
Abstract: M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed.
Conclusion: Even though M184V and L63P continue to be the most prevalent mutations for the reverse transcriptase and the protease genes, respectively, a descending trend was observed for mos
Result: As shown in Table 3, the PR-associated mutations with the highest degree of expression from 2006 to 2010 was L63P with frequencies of (525 of 707, 74.3%), (429 of 608, 70.6%), (494 of 706, 70.0%), (238 of 340, 70.0%), and (93 of 139, 66.9%), respectively.
Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naive Population from Northern India.
Result: Accessory minor PI mutations K20R, M36I, and H69K were seen in 7.3% (5/68), 97% (66/68), and 49% (33/68) patients, respectively; L63P, A71E, A71V, I13V, L10V, K45I, and K45R were observed in one patient each.
Short communication: Drug resistance mutations in the HIV type 1 protease and reverse transcriptase genes in antiretroviral-naive Vietnamese children.
PMID: 22260721
2012
AIDS research and human retroviruses
Abstract: Minor mutations were found in the protease gene, including L10I, I13V, G16E, M36I, D60E, I62V, I64V, L63P, H69K, V82I, and I93L.
The HIV type 1 protease L10I minor mutation decreases replication capacity and confers resistance to protease inhibitors.
PMID: 21142921
2011
AIDS research and human retroviruses
Abstract: Furthermore, viruses carrying the major mutation D30N or the minor mutation L10I showed a significant decrease in RC (p-value <0.05), whereas viruses carrying the minor mutation L63P had RC similar to wild-type virus.
Abstract: We characterized the HIV protease minor mutations, L10I, compared to the minor mutation, L63P, and the major mutation D30N and their impact on viral fitness and resistance to protease inhibitors.
Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.
Introduction: The authors reported a faster rate of reversion for primary resistance mutations (K70R, M184I/V, T215Y/F in RT, and D30N, M46I/L, V82A, L90M in PR) compared to secondary mutations (M41L, D67N, T69D/N, L210W, K219Q/E in RT and L10I/V, L63P, A71V/T, V77I in PR)
The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?
A Comparative Molecular Dynamics, MM-PBSA and Thermodynamic Integration Study of Saquinavir Complexes with Wild-Type HIV-1 PR and L10I, G48V, L63P, A71V, G73S, V82A and I84V Single Mutants.
PMID: 21453185
2011
AIDS research and human retroviruses
Abstract: Selection of T12S, I15V, L19I, M36I, R41K, H69K, L89M, and I93L was observed both in global and Indian subtype C while the L63P mutation was selected in Indian PR sequences.
Prevalence and resistance mutations of non-B HIV-1 subtypes among immigrants in Southern Spain along the decade 2000-2010.
Abstract: Patients infected with non-B subtypes showed a high frequency of minor protease inhibitor resistance mutations
Result: The M36I mutation in protease was observed in all patients, whilst K20I/R, L63P, V77I and L10V/I mutations were present in 75%, 17.8%, 10.7% and 7.1% of patients, respectively.
Table: L63P
Discussion: Our results indicated that patients infected with HIV-1 non-B subtypes showed a high frequency of minor PR mutations (polymorphisms) as M36I, L63P, and K20R/I, in contrast to the low proportion of major resistance mutations.
HIV mutation literature information.
PMID: 
2012
BMC infectious diseases
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