literature

HIV mutation literature information.

Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.

PMID: 23252515 2013 ACS chemical biology

Method: All protease genes, including wild type (WT), contained the polymorphism L63P.

Transmission patterns of HIV-subtypes A/AE versus B: inferring risk-behavior trends and treatment-efficacy limitations from viral genotypic data obtained prior to and during antiretroviral therapy.

PMID: 23469241 2013 PloS one

Result: The latter differed significantly in the frequencies of the major resistance RT mutations T215FY and K219QE (NRTI) and of several secondary/accessory mutations, including: the protease mutations I13V, M36I, I62V, L63P, A71V, V77I, L89M and I93L (Table 6) and the RT mutations A98S, K101N, K103R and V179I (Table 5).

Table:

PMID: 23592112 2013 Journal of medical virology

Discussion: A high frequency of minor PI resistance mutations (M36I, L63P, and K20R/I) has been reported in newly diagnosed immigrants from Spain, infected with non-B subtypes.

Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen.

PMID: 23687186 2013 The Journal of antimicrobial chemotherapy

Abstract: Specifically, the L10V + I13V + L63P + I93L cluster, related to fast virological failure, correlated with a decreased drug affinity for the enzyme in comparison with wild-type (DeltaGmut = -30.0 kcal/mol versus DeltaGwt = -42.3 kcal/mol).

Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study.

PMID: 23711895 2013 The Journal of antimicrobial chemotherapy

Abstract: Multiple novel mutations, I15S, L19T, K43T, L63P/V, K70Q, V77I and L89I/T/V, were also associated with atazanavir experience.

Result: In almost all patients in whom a baseline resistance test was available, the common M36I and Discussion: However, there was an increased frequency of several other mutations, including I15S, L19T, K43T, L63P/V, K70Q and L89I/T/V, which are not recognized to be associated with atazanavir by the most recent IAS classification.

Highly-sensitive allele-specific PCR testing identifies a greater prevalence of transmitted HIV drug resistance in Japan.

PMID: 24358257 2013 PloS one

Table: L63P

Discussion: Moreover, accumulation of compensatory mutations such as L63P and A71V in protease have been demonstrated to increase or restore replicative fitness of PI resistant variants, and that once compensation has taken place reversion to wildtype is prohibited by a less fit intermediate.

A Comparative Molecular Dynamics, MM-PBSA and Thermodynamic Integration Study of Saquinavir Complexes with Wild-Type HIV-1 PR and L10I, G48V, L63P, A71V, G73S, V82A and I84V Single Mutants.

PMID: 26587633 2013 Journal of chemical theory and computation

Abstract: In this work, we examine L10I, G48V, L63P, A71V, G73S, V82A, and I84V single mutant HIV-1 PR strains in complexes with saquinavir to elucidate drug-protease interactions and dynamics.

Abstract: It was shown that mutations conferring major resistance (G48V, L63P, I84V) did not present these interactions.

Abstract: It was shown that mutations, which increase the flexibility of the flaps (G48V, L63P, L10I) diminish binding.

Enhanced stability of monomer fold correlates with extreme drug resistance of HIV-1 protease.

PMID: 24079831 2013 Biochemistry

Abstract: However, without other compensatory mutations as seen in PR20, L33F and L63P substitutions, together, neither restrict autoproteolysis nor significantly reduce binding affinity to darunavir.

Abstract: Two specific mutations in PR20, L33F and L63P at sites of autoproteolysis, increase the Tm of monomeric PR(T26A) by ~8C, similar to PR20(T26A).

Introduction: Accessory mutations such as L10I, L63P and A71V have been shown to increase the thermal stability and pH tolerance of a drug resistant PR

Emergence of drug resistance-associated mutations in HIV-1 subtype C protease gene in north India.

PMID: 23888308 2013 Virus genes

Abstract: Approximately 70% polymorphisms as minor mutations were observed in protease gene, of which 14 distinct amino acids changes were linked to partial DR such as G16E, K20R, M36I, D60E, I62V, L63P, I64M, H69K, T74A/S, V77I, V82I, I85V, L89M, and I93L.

Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010.

PMID: 22593823 2012 AIDS research and treatment

Abstract: M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed.

Conclusion: Even though M184V and L63P continue to be the most prevalent mutations for the reverse transcriptase and the protease genes, respectively, a descending trend was observed for mos

Result: As shown in Table 3, the PR-associated mutations with the highest degree of expression from 2006 to 2010 was L63P with frequencies of (525 of 707, 74.3%), (429 of 608, 70.6%), (494 of 706, 70.0%), (238 of 340, 70.0%), and (93 of 139, 66.9%), respectively.

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