Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.
Result: L63P has been identified in drug resistant PR mutants and is classified as a minor drug resistance mutation, possibly associated with resistance to LPV.
Result: Mutations I62V and L63P in cluster 2 are common to PR20 and PRS17, and interestingly, also occur naturally in PR group O.
The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility.
Result: 4, when the baseline infectivity of F56C/L63P was matched to F56C and the parental virus (panel A), the double mutant exhibited IDV resistance similar to that observed for F56C alone (panel B) indicating that the L63P polymorphism made no detectable contribution.
Result: L63P is a common polymorphism, however, its frequency was found to increase in PR inhibitor-treated patients.
Result: For these studies, we combined the most radical of these substitutions, L63P, with the S40A/F56C mutation forming F56C/L63P.
Result: Moreover, covariance analysis indicated
Cross-sectional study of virological failure and multinucleoside reverse transcriptase inhibitor resistance at 12 months of antiretroviral therapy in Western India.
Result: Only 1 individual had major PI resistance mutation L90M and 5 had minor PI resistance mutations L89M, V77I, L63P, H69K/R/Q, M36I, K20I/M/R/T, G16E, and L10V/I.
Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.
Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa.
PMID: 26258548
2015
AIDS research and human retroviruses
Abstract: Before bPI, significant variation in Protease and Gag was observed at positions previously associated with PI exposure and resistance including Gag mutations L449P, S451N, and L453P and Protease K20I an
Introduction: Of particular relevance to this study were mutations associated with resistance to boosted lopinavir: L10I (three subtype A patients), L10V (one subtype A), K20R (five subtype As and 1 subtype C), L33V (one subtype D), L63P (one subtype A, two subtype Cs, and three subtype Ds).
Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.
Introduction: Similarly, the I50V mutation in flap regions selected by APV shows more flexible flaps, and single mutation distant from flap regions such as L63P or L10I can increase the flexibility of flap regions as well.
Discussion: Through comparing the crystal structures of APV and DRV bound WT HIV-1 PR and its MDR variant (L63P, V82T, and I84V) and calculating their corresponding binding thermodynamics, King et al.
Modulation of HIV protease flexibility by the T80N mutation.
Result: Classifying the HIVp samples by the parameters c and e, the T80N mutant clusters with the inhibitor-bound forms rather than the functional apo forms of WT and G48V L63P (Fig 5).
Result: Solution scattering data were collected from a series of HIVp variants which included: WT, T80N, and the flap variant G48V that included the secondary mutation L63P.
Result: The addition of pepstatin inhibitor to either WT or the G48V/L63P mutant results in a large reduction in the flexibility of these proteins such that they approach the reduced levels of motion observed for the T80N mutant.
Result: Vector-length convolution calculations were carried out to fit WAXS patter
Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
Introduction: The other mutations which were co-occurring with DBM and TPM included major mutations like- M46IL, I54MV, I84V, L90M, N88S, V32I, I47V, V82AS, D30N, G48V; and accompanied by minor mutations like- L10I, I13V, L63P, A71V, L89M, I93L, E35DN, I15V, D60E, L24I etc.
Transmitted Drug Resistance Mutations in Antiretroviral-Naive Injection Drug Users with Chronic HIV-1 Infection in Iran.
HIV mutation literature information.
PMID: 
2016
Biochemistry
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