Discussion: In our sequences from INSTI-naive patients, we observed that some polymorphisms changed their prevalence according to prior ARV (NRTI/PI) exposure: V19M and L58V significantly increased their frequency in NRTI/PI-treated patients, while E246D and M277L significantly decreased their frequency in this group.
Genetic and functional analysis of HIV type 1 nef gene derived from long-term nonprogressor children: association of attenuated variants with slow progression to pediatric AIDS.
PMID: 22583022
2012
AIDS research and human retroviruses
Abstract: The emergence or presence of Nef L58V substitution was associated with viral attenuation, indicated by a reduction in HIV viral loads, a persistent preservation of CD4(+) T cell counts, and lack of AIDS-related symptoms.
HIV mutation literature information.
PMID: 
2014
PloS one
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