Analysis of HIV type 1 gp41 and enfuvirtide susceptibility among men in the United States who were HIV infected prior to availability of HIV entry inhibitors.
PMID: 19552592
2009
AIDS research and human retroviruses
Introduction: Five samples with E137K and one sample with S138A also had N42S; one sample with E137K also had N42S and L44M.
Introduction: The N42S polymorphism was detected in 28 (16%) of the 175 samples, including two samples that also had L44M, one of which also had Introduction: Using the Stanford HIV Resistance Database as a reference, we identified minor HR1 mutations associated with reduced susceptibility to ENF in 6 (3.4%) of 175 samples from men in the EXPLORE cohort (V38G, N43K, L44M, and L45M).
Table: L44M
Natural resistance-associated mutations to Enfuvirtide (T20) and polymorphisms in the gp41 region of different HIV-1 genetic forms from T20 naive patients.
Abstract: In particular, these mutations clustered in two distinct regions: (i) a mutational hot-spot localized, as previously described, in the first residues of the N-HR domain, with position number 38 as the most heavily mutated, but including also a G36V, a N42D/T, a N43D, a L44M and a L45M; (ii) other mutations were localized further downstream, within N-HR/C-HR junction and in the C-HR.
HIV mutation literature information.
PMID: 
2009
AIDS research and human retroviruses
Browser Board
Co-occurred Entities
Filtrator
ViMRT