Abstract: RESULTS: The ddI resistance mutations and their resistance scores based on the derivation set were as follows: M41L (score of 14), T69D (24), D123S (40), T139M (54), I180V (53), M184V (-12), V189I (55), Q207K (37), L210W (25), and T215Y (eight).
Level of viral load and antiretroviral resistance after 6 months of non-nucleoside reverse transcriptase inhibitor first-line treatment in HIV-1-infected children in Mali.
PMID: 19933171
2010
The Journal of antimicrobial chemotherapy
Abstract: Among the children with detectable VL, 30/37 genotypic resistance tests were available, 8 with wild-type viruses and 22 with resistance mutations (73%): 19 M184V/I, 21 NNRTI mutations and only 3 thymidine analogue mutations (TAMs) (K70R, D67N and L210W in three distinct viruses).
Low-abundance HIV species and their impact on mutational profiles in patients with virological failure on once-daily abacavir/lamivudine/zidovudine and tenofovir.
PMID: 20008905
2010
The Journal of antimicrobial chemotherapy
Introduction: M41L, D67N, K70R, L210W, T215F/Y and K219Q/E), such that they are rarely detected in vivo in the same sample by popul
Table: L210L/W
Table: L210W
Discussion: In their cross-study comparison, they concluded that this regimen was an efficient treatment strategy in moderately pre-treated patients and that virological success was observed for this regimen in the presence of the M184V mutation and low numbers of TAMs, although the presence of at least two TAMs, especially when the T215Y/F mutation was present, or the L210W mutation alone was a predictor of VF.
N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations.
Introduction: N348I also increased tenofovir resistance when combined with M41L, L210W and T215Y (HX/3AZT) by 6.0-fold compared to WT (p= 0.009, n=5) and 3-fold compared to the HX/3AZT strain (p=0.008, n=4).
Introduction: N348I was introduced by site directed mutagenesis into the background of wild-type (WT), K103N, Y181C, M41L/L210Y and Introduction: According to the International AIDS Society-USA drug resistance mutations update, the presence of 3 or more TAMs inclusive of M41L and L210W is expected to give a reduced in vivo response to tenofovir.
Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive HIV-infected patients.
PMID: 20380480
2010
AIDS research and human retroviruses
Abstract: In the four FPV/r-treated VFs, baseline HIV TAMs combinations and/or PI mutations were detected in one by PG at VF (RT: L210W + T215C; PR: M46I + L76V) and three others by CA alone (RT: L210W + T215Y; RT: M41L; RT: K65R + K70R; PR: I47V); all four had study drug-associated mutations (CA detecting more HIV-1 resistance mut
Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations.
PMID: 20462946
2010
The Journal of antimicrobial chemotherapy
Method: We also examined the extent to which the 52 NNRTI-selected mutations covaried with mutations at 12 major nucleoside reverse transcriptase inhibitor (NRTI) resistance positions, including M41L, K65R, D67N, T69S_SS, K70E, K70R, L74V, L74I, V75M/T, Y115F, Q151M, M184V/I, L210W, T215F and T215Y.
Result: The NNRTI
Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naive subjects in the CASTLE study.
Introduction: This region includes the following important and well-defined drug resistance mutations to nucleoside RT inhibitors (NRTIs) and non-nucleoside RT inhibitors
Table: L210W
Figure: Frequency of resistance drug resistance mutations M184V, T215Y, L210W and T215C/D before, during and after treatment.
Discussion: This was accompanied by a gradual increase in the prevalence of variants with specific linked drug resistance mutations (in particular variants with M184V+T215Y and M184V+L210W+T215Y) (Table 4.
Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors.
PMID: 20817922
2010
The Journal of antimicrobial chemotherapy
Abstract: Similarly, V165I and G163R mutations were associated with the RT resistance mutations F227L and M230L, respectively, and the T206S polymorphism was associated with the RT resistance mutation L210W.
HIV mutation literature information.
PMID: 
2010
AIDS (London, England)
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