Abstract: Amino acid variation at
reverse transcriptase (
RT) codon 210 (generally
Leu-210 to Trp [
L210W], TTG-->TGG) is occasionally detected after the initiation of azidothymidine (AZT) therapy.
Abstract: In summary, the
L210W mutation appears to be of marginal significance, conferring approximately two- to fourfold-reduced sensitivity to AZT compared with similar AZT-resistant genomes with L-210.
Abstract: The frequency and genetic background of the
L210W mutation in vivo were assessed by analyzing sera of AZT-naive and AZT-experienced patients by
RT-PCR and DNA sequencing.
HIV mutation literature information.
PMID: 
1996
Journal of virology
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