Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice.
PMID: 34327247
2021
Open forum infectious diseases
Method: The variables expressing NRTI RAMs were identified as follows: (1) presence versus absence of any NRTI RAM; (2) presence versus absence of at least 1 TAM (M41L, D67N, K70R, L210W, T215Y/F, K219Q/E); (3) presence versus absence of M184V/I (with or without other RAMs); (4) presence versus absence of M184V/I not associated with TAMs; (5) presence versus absence of M184V/I combined with at least 1 TAM.
Table: L210W
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.
Result: Thymidine analog mutations (TAM) were detected in 35.4% of the individuals [17.1% (14/82) TAM-1 (including M41L, L210W, and T215Y) and 20.7% (17/82) TAM-2 (including D67N, K70R, T215F, and K219Q/E)].
Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.
Method: Thymidine-analog mutations were defined as the NRTI-SDRMs M41L, D67N/G/E, K70R, L210W, T215Y/F/S/C/D/E/I/V, and K219Q/E/N/R.
Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda.
Abstract: As expected, discriminatory DRMs such as K65R, L74I, and Y115F were noted in Tenofovir (TDF) containing regimens while the Thymidine Analogue Mutations (TAMs) L210W and T215 mutations were in Zidovudine (AZT)-based regimens.
Result: As expected, L210W (75%, p = 0.03) and T215 mutations (70%, p = 0.0005) were significantly noted more in AZT/3TC/EFV as compared to TDF/3TC/EFV group.
Result: However, comparisons for individual mutations within the NRTI class of drugs indicated that mutations K65R, L74I, Y115F, L210W and T215 mutations differed significantly among the two regimens.
Discussion: On the other hand, mutation
Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China.
Abstract: In HIV-1, resistance to zidovudine and other thymidine analogues is conferred by different combinations of M41L, D67N, K70R, L210W, T215F/Y, and K219E/Q (designated as thymidine analogue resistance-associated mutations (TAMs)).
HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naive HIV-infected individuals.
HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.
PMID: 31774913
2020
The Journal of infectious diseases
Method: Because some individuals may have been exposed to thymidine analogs before TDF-containing regimens, we excluded individuals with sequences containing TAMs:M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E.
HIV mutation literature information.
PMID: 
2021
Open forum infectious diseases
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