Abstract: Fifty-seven samples had at least one TDR-associated mutation, mainly including L10I/V (6.3%), A71L/T/V (6.3%), V179D/E (5.4%), and V106I (2.7%), with different distributions of TDR-associated mutations by different HIV-1 subtypes and by each year.
Result: PI mutations included L10I/V (7.2%, 16/223) and A71L/T/V (6.3%, 14/223), with relatively high frequency; NRTI mutations, included L74I (0.45%, 1/223) and V75L (0.45%, 1/223); and the most frequent NNRTI mutation was V179D/E (5.4%, 12/223).
Result: The proportion
HIV-1 diversity, transmission dynamics and primary drug resistance in Angola.
Result: The minor resistance mutations L10I and L10V, associated with resistance to most of the PIs when present with other mutations, were found in 15.7% and 17.6% of the isolates, respectively (Table S1).
The prevalence of transmitted HIV drug resistance among MSM in Anhui province, China.
Result: However, some accessory mutations that did not affect susceptibility to ARV drugs were found in the protease gene, including L10I/L/V (3.0%; 4/133), V11I/V (3.0%; 4/133), L33F (2.3%; 3/133), and A71A/V/T (12.8%; 17/133).
Discussion: For example, L10V, V11I/V, L33F, T69A/N/S, and P236L were present only in individuals with CRF01_AE strains.
Discussion: Other commonly observed mutations were T69A/N/S, V179E, L10I/L/V, V11I/V,
The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics.
Introduction: The DetMDRs also contain previously identified non-polymorphic accessory mutations L10V/G, V11I, I13V, K20T/R, L33F/I/M, K43T, F53L, A71L, T74P, and L89V.
Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen.
PMID: 23687186
2013
The Journal of antimicrobial chemotherapy
Abstract: Specifically, the L10V + I13V + L63P + I93L cluster, related to fast virological failure, correlated with a decreased drug affinity for the enzyme in comparison with wild-type (DeltaGmut = -30.0 kcal/mol versus DeltaGwt = -42.3 kcal/mol).
Transmission patterns of HIV-subtypes A/AE versus B: inferring risk-behavior trends and treatment-efficacy limitations from viral genotypic data obtained prior to and during antiretroviral therapy.
Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study.
PMID: 23711895
2013
The Journal of antimicrobial chemotherapy
Result: The remaining 43 minor atazanavir mutations were either not detected in this dataset (L10C, K20V, E34Q, F53Y, I54L/M/T/A, A71L, G73C/T, V82F and I93M) or were not significantly associated with atazanavir exposure (L10I/F/V, G16E, K20R/M/I/T, L24I, V32I, L33I/F/V, M36L/V, M46L, G48V, I54V
Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa.
Discussion: The secondary substitution was L10V in two viruses (7%), whereas K20R occurred in four (14%) of the 29 isolates.
Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender, and age issues.
PMID: 21936717
2012
AIDS research and human retroviruses
Abstract: The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and PMID: 22496972
2012
AIDS research and treatment
Result: Accessory minor PI mutations K20R, M36I, and H69K were seen in 7.3% (5/68), 97% (66/68), and 49% (33/68) patients, respectively; L63P, A71E, A71V, I13V, L10V, K45I, and K45R were observed in one patient each.
HIV mutation literature information.
PMID: 
2014
BMC infectious diseases
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