Result: Although NNRTIs were not used in this study, a minor NNRTI mutation K101K/E, as well as the 2 minor PI mutations L10F and L33F emerged at VF and RS to FPV was observed.
The use of dried blood spot specimens for HIV-1 drug resistance genotyping in young children initiating antiretroviral therapy.
PMID: 26192603
2015
Journal of virological methods
Introduction: Only one specimen was predicted to be resistant to protease inhibitors (PI) due to the presence of major and minor PI mutations (L10F, M46I, I54V, L76V and V82A) while 8 specimens had minor PI mutations (A71T (n=3), L10I/V (n=3) and M46L/T (n=2)).
Conformational variation of an extreme drug resistant mutant of HIV protease.
PMID: 26397743
2015
Journal of molecular graphics & modelling
Method: Plasmid DNA encoding PR (subtype B of group M) with 20 mutations Q7K; L10F; I13V; I15V; D30N; V32I; L33F; E35D; M36I; S37N; I47V; I54L; Q58E; I62V; L63P; A71V; I84V; N88D; L89T and L90M (termed PR20) cloned between the Nde1 and BamH1 sites
The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.
Result: In the experienced subgroup, at least seven major (M46I, V82A, I54V, L90M, I84V, M46L, and L76V) and 15 accessory mutations (I62V, A71V, L10I, L10V, K20R, L33F, Q58E, K20T, L10F, T74S, F53L, K43T, G73S, I85V, and A71I) developed and were ass
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
Result: Of the 243 patients who received one or more protease inhibitors, 32 (13%) had a study-defined protease inhibitor-resistance mutation most commonly L10F, K20T, V32I, L33F, M46I/L, I47V/A, I50L, F53L, I54V/L, Q58E, L76V, V82A/C, I84V, L89V, and L90M.
Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.
Result: Although PR20 does not show a predominant closed flap orientation in the absence of inhibitor, this construct also contains the following mutations considered to be within the hydrophobic core: L10F/I13V/I15V/I33F/M36I/-I62V/L90M.
Structures of darunavir-resistant HIV-1 protease mutant reveal atypical binding of darunavir to wide open flaps.
Result: Unlike the mutated side chain of L10F in PR20/DRV, in which a new hydrophobic contact was formed between the side chains of Phe10 and mutated Ile82, mutated residue L10I in PRP51-D25N yields no new interactions with nearby residues.
Prevalence and mutation patterns of HIV drug resistance from 2010 to 2011 among ART-failure individuals in the Yunnan Province, China.
Result: The DRM, ANAM-11, bears six mutations identical or similar to PR20 (L10I/F, M36I, L63P, A71V, I84V, L90M) and exhibits similar properties of increased dimer dissociation (Kd = 0.1 +- 0.04 muM) along with moderately enhanced thermal stability (Table 1A).
HIV mutation literature information.
PMID: 
2015
The open AIDS journal
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