literature

HIV mutation literature information.

Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia.

PMID: 32804970 2020 PloS one

Result: The N88S was the only major PI mutation (1.7%) and there were three PI-Accessory mutations of L10LF (1.7%), K20T (1.7%) and Q58E (5.2%).

Genotyping and antiretroviral drug resistance of human immunodeficiency Virus-1 in Jazan, Saudi Arabia.

PMID: 33285702 2020 Medicine

Abstract: Mutations associated with antiretroviral drugs include (V82A+I84IV), (L10F+Q58E), (L10F+V82Y), L10FV, L33LF, L89LMV, M184V, E138A, V106I, and V179VD.

Result: Among the observed resistance mutations, 4/57 (7.0%) had conferring resistance to PI, other detected mutations were (L10F + V82Y), L10FV, L33LF, and

PMID: 33654530 2020 The Pan African medical journal

Table: L10F

First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens.

PMID: 32843050 2020 Antimicrobial resistance and infection control

Conclusion: Detected RAMs were M41L, K70Q, V75I, Q151M, M184V and T215F for NRTI; K103N and V108I for NNRTI; and L10F, K20I, M36I, M46I, I47V, I54L, L63H, L76V, V82S and L89I for PI/r.

Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana.

PMID: 32709248 2020 Virology journal

Table: L10F

Discussion: The accessory and minor mutations found were F77L and L10F in RT gene and PR gene respectively.

Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.

PMID: 32576136 2020 BMC infectious diseases

Result: The most common mutations in NNRTIs were K103N/KN (64.69%), V179D/E (23.47%) and Y181C/YC/I (14.00%), they were M184V/MV/I (36.29%), T215F/FS/TNSY (7.50%) and K219Q (5.92%) in NRTIs, and they were Q58E/QE (4.93%), L10F/LFI (0.39%) and M46L (0.39%) in PIs.

Figure: Note: PIs mutations: M46I, I54V, V82A, K20T,

HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naive HIV-infected individuals.

PMID: 32119691 2020 PloS one

Table: L10F

Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern Tanzania.

PMID: 32986709 2020 PloS one

Table: L10F

High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014.

PMID: 30640198 2019 The Pediatric infectious disease journal

Result: The other eight children had accessory PI mutations (L10F, L33F, K43T, and Q58E).

Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province, China.

PMID: 30621727 2019 Virology journal

Abstract: Furthermore, L10 V/F/I (6.82%), A71V (4.55%), and I54V (4.55%) mutations were common in protease inhibitors (PIs).

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