literature

HIV mutation literature information.

HIV-1 drug resistance profiling using amino acid sequence space cartography.

PMID: 35157024 2022 Bioinformatics (Oxford, England)

Abstract: V32I, L10F, and L33F in HIV protease) for the resistance development.

Detection of Gag C-terminal mutations among HIV-1 non-B subtypes in a subset of Cameroonian patients.

PMID: 35082353 2022 Scientific reports

Introduction: Following the Stanford algorithm (mutation list), minor resistance mutations (L10F, V11I, K20TV, L23I, L33F, K43T, F53L, Q58E, A71IL, G73STCA, T74P, N83D, and L89V) are assumed to have ancillary roles such as compensation for lower efficiency of proteolysis caused by major mutations; major resistance mutations (V32I, M46IL, I47VA, G48VM,

PMID: 35061671 2022 PloS one

Result: The most prevalent PI DRMs were M46I (3/120; 2.5%) and L10F (2/120; 1.7%) in Armenia and N88D (2/96; 2.1%) in Azerbaijan.

Table: L10F

Discussion: The most frequent PI DRMs included M46I and L90M, which are associated with DR to nelfinavir, which was not considered for PDR estimation and has not been used since 2013; additionally, N88D and L10F only minimally reduce susceptibility to drugs.

Correlation of HIV-1 drug resistant mutations and virologic failure.

PMID: 34584606 2021 The Pan African medical journal

Table: L10F

HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China.

PMID: 33668946 2021 Pathogens (Basel, Switzerland)

Result: Other PI-related mutations such as L10F, I47V, I50V, F53L, I54VT and N83D have the mutation frequency of about 2%.

Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naive HIV Patients in Southeast China.

PMID: 33679129 2021 Drug design, development and therapy

Abstract: Two individuals harbored PIs-resistance mutations: Q58E in one patient and M46I, I54V, V82A, L10F, and Q58E mutations in another patient.

Result: Two patients harbored PIs-resistance mutations: Q58E mutation in one patient, 3 major mutations (M46I, I54V, V82A) and 2 accessory mutations (L10F, Q58E) in another individual (Table 2).

Acquired HIV-1 Protease Conformational Flexibility Associated with Lopinavir Failure May Shape the Outcome of Darunavir Therapy after Antiretroviral Therapy Switch.

PMID: 33805099 2021 Biomolecules

Abstract: The HIV-1 protease variants were from clinical isolates with a combination of drug resistance mutations; MUT-1 (M46I, I54V, V82A, and L10F), MUT-2 (M46I, I54V, L76V, V82A, L10F, and L33F), and MUT-3 (M46I, I54V, L76V, V82A, L90M, and F53L).

Introduction: The minor drug resistance mutations are L10F located around the fulcrum, and the F53L<

Understanding the co-evolutionary molecular mechanisms of resistance in the HIV-1 Gag and protease.

PMID: 34253143 2021 Journal of biomolecular structure & dynamics

Abstract: Here we showed that distinct changes in PR's active site, flap and elbow regions due to several PR resistance mutations (L10F, M46I, I54V, L76V, V82A) were found to alter LPV and DRV drug binding.

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Abstract: Three candidate PI-SDRMs were accessory darunavir-resistance mutations (L10F, T74P, L89V).

Result: L10F has been shown to be an accessory DRM associated with reduced in vitro lopinavir and darunavir susceptibility.

Result: Figure 3 shows the locations of the PI-SDRMs and the three candidate mutations (L10F, T74P, and L89V) within the three-dimensional structure of HIV-1 protease.

Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana.

PMID: 32709248 2020 Virology journal

Table: L10F

Discussion: The accessory and minor mutations found were F77L and L10F in RT gene and PR gene respectively.

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