literature

HIV mutation literature information.

Low prevalence of transmitted drug resistance in patients newly diagnosed with HIV-1 infection in Sweden 2003-2010.

PMID: 22448246 2012 PloS one

Table: K70R

Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP.

PMID: 22536497 2012 AIDS research and treatment

Discussion: The group found H221Y was strongly associated with the use of NVP and showed positive interactions with Y181C and was also negatively associated with the use of ZDV and with TAMs (particularly TAMs-2, such as D67N, K70R, K219Q/E, and T215F) and was then associated with an increased susceptibility to ZDV.

Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.

PMID: 22592583 2012 Journal of acquired immune deficiency syndromes (1999)

4Method: ARV resistance was defined by mutations at the following positions: M41L, A62V, K65R, D67N, T69ins, K70R, L74VI, Y115F, F116Y, Q151M, M184VI, T210W, T215YF and K219QE for Result: D67N(P=0.03), K70R(P=0.06), M184V(P=0.11), L210W(P=0.11), and K219Q(P=0.02) decreased during the study period.

Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010.

PMID: 22593823 2012 AIDS research and treatment

Result: Statistically significant differences between men and women were observed for K70R (P = 0.04) and K219Q (P = 0.03) in 2006, K103N (P = 0.02) in 2007, K219E (P = 0.03) in 2009 (data not shown), and V118I (P = 0.03) in 2010.

Discussion: The statistically significant results for the reverse transcriptase mutation K70R have been noted for 2003 and 2006, while gender differences for K103N were observed in 2005 and 2007.

K65R in subtype C HIV-1 isolates from patients failing on a first-line regimen including d4T or AZT: comparison of Sanger and UDP sequencing data.

PMID: 22615779 2012 PloS one

Method: Positions studied were codon 65 and codon 70, which was chosen as a TAM position in NRTI-treated patients leading to K70R, because it has been frequently observed in the studied isolates and because 70R is considered to be a DRM and not at all a substitution potentially related to polymorphism.

Result: K70R was <0.4% by UDPS in all isolates from naive patients.

Result: K70R with UDPS ranged from <0.4% to 100%.

Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia.

PMID: 22729198 2012 The Brazilian journal of infectious diseases

Abstract: The most prevalent RT mutations were T215F/V/Y (66.7%), D67G/N (55.6%), K219Q/E/R (44.4%), M184V/I (38.9%), K70R/E (27.8%) and M41L (27.8%), associated with nucleoside reverse transcriptase inhibitors (NRTI) resistance; and K103N (55.6%), G190A (33.3%), and K101P/E/H (27.8%) associated with non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance.

Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.

PMID: 22828721 2012 Journal of acquired immune deficiency syndromes (1999)

Method: Thymidine analogue mutations (TAMs) were defined as M41L, D67N, K70R, L210W, T215F/Y, K219E/Q.

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy.

PMID: 22889300 2012 Retrovirology

Introduction: However, combinations of M41L, D67N, K70R, L210W, T215F/Y and K219E/Q increase ATP-mediated excision of chain-terminating NRTIs (reviewed in ref.).

Introduction: Sequence analysis of HIV-1 isolates from patients receiving long-term therapy with AZT and/or d4T revealed that thymidine analogue resistance mutations (TAMs) acting through the excision mechanism associated in two different clusters: TAM1 (M41L, L210W and T215Y) and TAM2 (D67N, K70R, K219E/Q, and sometimes T215F).

HIV-1 drug resistance genotyping from antiretroviral therapy (ART) naive and first-line treatment failures in Djiboutian patients.

PMID: 23044036 2012 Diagnostic pathology

Discussion: Accumulation of the other mutations observed included thymidine associated mutations (including M41L, D67N, K70R, L210W, T215Y/F, K219Q) results in increasing resistance to AZT, Tenofovir, D4T, Abacavir, and DDI .

Differential in vitro kinetics of drug resistance mutation acquisition in HIV-1 RT of subtypes B and C.

PMID: 23056372 2012 PloS one

Table: K70K/R

Table: K70R

Discussion: However, RTC and RTC' data suggest that D67N and K70R were selected instead of T215F and then directed to TAM-2.

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