Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients.
Abstract: Thymidine analogue resistance mutations (TAMs) in HIV-1 reverse transcriptase (RT) associate in two clusters: (i) TAM1 (M41L, L210W and T215Y) and TAM2 (D67N, K70R, K219E/Q, and sometimes T215F).
Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.
Result: The codons T12, N37, L63, H69, K70 and I72 include mutations weakly associated with PI resistance (T12A/I, N37D/E, L63A, H69Y, K70E, and I72R), and mutations lacking evidence of PI resistance (T12P/S, N37S/T/C/H/I, L63S/V/R/G/H, H69Q, K70R/T/I, and I72V/T/E/M).
Table: K70R/T
Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.
Method: In this study, HIV-2 resistance mutations were identified using the list generated by the 'Collaborative HIV and Anti-HIV Drug Resistance Network', leading to the following mutations in reverse transcriptase - K65R, D67G/N, N69S/T, K70N/R, L74V, V111I, Y115F, M184I/V, Q151M, S215A/C/F/L/Y, K223R; and in protease - V47A, G48V, I50V, I54L/M,
HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study.
Persistence of HIV-1 transmitted drug resistance mutations.
PMID: 23904291
2013
The Journal of infectious diseases
Result: M41L was commonly observed and highly persistent (rate of loss 8 (95% CI, 4-15) per 100 PYFU), and a similar low rate of loss was seen for other TAMs (D67N, L210W, and K219Q/N); however, K70R appeared to be lost more quickly.
Table: K70R
Discussion: In a recent study of patients with acute/early infection all TAMs were combined for analysis, but we found marked variation within this group of mutations, with T215F/Y and K70R being lost more rapidly than other TAMs.
Discussion: They reported that at least 2 mutations (K70R and Y181C) could form self-sustaining transmission chains.
Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance.
Method: Vectors pHL[B-TAMs] and pHL[C-TAMs] were created by introducing NRTI resistance mutations D67N, Result: Inherent levels of AZT resistance were first tested for wild-type subtype C in the absence (C-WT) or presence (C-TAMs) of TAMs (D67N, K70R, T215F/Y and K219Q).
Result: We have previously shown that the difference in AZT resistance between TAMs combination D67N, K70R, T215Y and K219Q versus D67N, K70R, T215F and K219Q in a subtype B background is ~1.6-fold.
Tenofovir-based regimens associated with less drug resistance in HIV-1-infected Nigerians failing first-line antiretroviral therapy.
Method: Thymidine analog mutations (TAMs) included M41L, D67N, K70R, L210W, T215F/Y, K219E/Q) that were further designated as TAM 1 (M41-L210-T215Y) or TAM 2 (D67-K70-T215F-K219).
From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-Festinavir.
Introduction: A012D contains four NRTI-associated mutations (NAMs) (D67K, K70R, T215F and K219Q), which confer a high level (210-fold) resistance to zidovudine.
Antiviral resistance and correlates of virologic failure in the first cohort of HIV-infected children gaining access to structured antiretroviral therapy in Lima, Peru: a cross-sectional analysis.
Result: The M184V reverse transcriptase mutation was detected in 80% of the sequenced RNA samples and tested positive in 74% and 47% by RNA-OLA and DNA-OLA, whereas thymidine associated mutations (TAMs: M41L, D67N, K70R, L210W, T215F/Y, K219Q/E) were detected in 50% of sequenced viral RNA.
HIV mutation literature information.
PMID: 
2014
Antiviral research
Browser Board
Co-occurred Entities
Filtrator
ViMRT