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 HIV mutation literature information.


  Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance.
 PMID: 7509370       1994       The Journal of general virology
Abstract: High level resistance to 3'-azido-3'-deoxythymidine (AZT, zidovudine or Retrovir) is conferred by the presence of four or five mutations (Met-41-->Leu; Asp-67-->Asn; Lys-70-->Arg; Thr-215-->Tyr or Phe; Lys-219-->Gln) in the human immunodeficiency virus (HIV) reverse transcriptase.


  Biochemical and genetical analysis of AZT-resistant HIV-mutants.
 PMID: 1930105       1991       Behring Institute Mitteilungen
Abstract: the Lys 70----Arg and the Thr 215----Tyr transitions.


  Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).
 PMID: 2479983       1989       Science (New York, N.Y.)
Abstract: Comparative nucleotide sequence analysis of the reverse transcriptase (RT) coding region from five pairs of sensitive and resistant isolates identified three predicted amino acid substitutions common to all the resistant strains (Asp67----Asn, Lys70----Arg, Thr215----Phe or Tyr) plus a fourth in three isolates (Lys219----Gln).



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