Result: Taking into account multiple mutations together, the thymidine analog mutations (TAM) pathway 1 (including M41L, L210W, and T215Y) was selected in 40.8% of the patients, whereas TAM-2 (including D67N, K70R, T215F, and 58 K219Q/E) was present in 42.2%.
Result: The most prevalent mutations related to NRTIs were M184V (80.1%), followed by M41L (31.8%), T215Y (30.2%), D67N (25.5%), K70R (24.4%), T215F (18.3%), L210W (15.1%), and V118I
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
Discussion: Indeed, other NRTI DR mutations as M41L, D67N, K70R, L210W, and T215Y/F.
Discussion: We observed a significant decrease in the frequency of NRTI PDR mutations (D67N, K70R, M184V, T215Y) and an increase in the frequency of K103N (Fig 4), consistent with a long-term decrease in NRTI PDR and increase in NNRTI PDR in Honduras since the beginning of the national ART programme.
Outcome of patients on second line antiretroviral therapy under programmatic condition in India.
Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns.
Discussion: This report indicated that K70R was followed by T215Y and accumulated the cluster mutation M41L/D67N/K70R/T215Y (K219Q), but herein we observed no cluster.
HIV-1 subtype characteristics of infected persons living in southwestern Greece.
Result: Less frequent substitutions identified in the subtype-A1 sequences of the study group involved I15V, G16E, R41K, K45R, and K70R (<60% of cases).
Result: The 22 cases experiencing virologic failure presented with the following DRMs: M46I, F53LY, I54LTV, G73ST, L76V, V82AT, I84V, I185V, N88D, and L90M for PIs; L100I, K103NS, PMID: 26717411
2015
PloS one
Result: K70R, L74V/I, Y115F
Result: Fig 2 shows that in viruses from individuals in LMICs with intermediate or high-level NRTI resistance following VF on a first-line NRTI/NNRTI-containing regimen, the most common major DRMs were M184V (91.5%) and M184I (3.7%), K65R (9.8%), and the TAMs K70R (14.6%), T215Y (11.0%) and T215F (9.3%).
The development of drug resistance mutations K103N Y181C and G190A in long term Nevirapine-containing antiviral therapy.
Result: It showed that M41L, D67N, T69D, K70R, and K219R were the most common NRTI mutations that associated with the three NNRTI mutations, K103N, Y181C and G190A.
Table: K70R
Frequency of Antiretroviral Resistance Mutations among Infants Exposed to Single-Dose Nevirapine and Short Course Maternal Antiretroviral Regimens: ACTG A5207.
PMID: 26525108
2014
Journal of AIDS & clinical research
Abstract: Among the 2 infants with NRTI mutations, one (K70R) was likely maternally transmitted and one (K65R) occurred in the context of breastfeeding exposure to maternal antiretroviral therapy.
Result: Of these, one mother/infant pair was concordant for K70R; the mother received antenatal ZDV and 7 days of LPV/r study treatment, and the infant was not breast fed.
Discussion: One infant had a new K70R mutation, concordant with a maternal K70R mutation and in the context of antenatal and infant ZDV.
Discussion: These findings suggest that the infant K70R mutation may have been of maternal origin, possibly related to antenatal ZDV exposure.
HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya.
Abstract: Eight (8) patients had NRTI resistance mutations with NAMS M184V (54.2%) and K65R (8.4%) mutations being the highest followed by TAMs T215Y and K70R (12.5%).
Result: Of the 6 patients who harboured TAMs mutations, only 3 of them had T215Y mutations while 3 had K70R mutations among those who were on or on a previous AZT treatment.
Table: K70R
Use of dolutegravir in two INI-experienced patients with multiclass resistance resulted in excellent virological and immunological responses.
PMID: 25397500
2014
Journal of the International AIDS Society
HIV mutation literature information.
PMID: 
2015
BioMed research international
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