Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns.
Discussion: This report indicated that K70R was followed by T215Y and accumulated the cluster mutation M41L/D67N/K70R/T215Y (K219Q), but herein we observed no cluster.
HIV-1 subtype characteristics of infected persons living in southwestern Greece.
Result: Less frequent substitutions identified in the subtype-A1 sequences of the study group involved I15V, G16E, R41K, K45R, and K70R (<60% of cases).
Result: The 22 cases experiencing virologic failure presented with the following DRMs: M46I, F53LY, I54LTV, G73ST, L76V, V82AT, I84V, I185V, N88D, and L90M for PIs; L100I, K103NS, PMID: 26717411
2015
PloS one
Result: K70R, L74V/I, Y115F
Result: Fig 2 shows that in viruses from individuals in LMICs with intermediate or high-level NRTI resistance following VF on a first-line NRTI/NNRTI-containing regimen, the most common major DRMs were M184V (91.5%) and M184I (3.7%), K65R (9.8%), and the TAMs K70R (14.6%), T215Y (11.0%) and T215F (9.3%).
The development of drug resistance mutations K103N Y181C and G190A in long term Nevirapine-containing antiviral therapy.
Result: It showed that M41L, D67N, T69D, K70R, and K219R were the most common NRTI mutations that associated with the three NNRTI mutations, K103N, Y181C and G190A.
Table: K70R
Frequency of Antiretroviral Resistance Mutations among Infants Exposed to Single-Dose Nevirapine and Short Course Maternal Antiretroviral Regimens: ACTG A5207.
PMID: 26525108
2014
Journal of AIDS & clinical research
Abstract: Among the 2 infants with NRTI mutations, one (K70R) was likely maternally transmitted and one (K65R) occurred in the context of breastfeeding exposure to maternal antiretroviral therapy.
Result: Of these, one mother/infant pair was concordant for K70R; the mother received antenatal ZDV and 7 days of LPV/r study treatment, and the infant was not breast fed.
Discussion: One infant had a new K70R mutation, concordant with a maternal K70R mutation and in the context of antenatal and infant ZDV.
Discussion: These findings suggest that the infant K70R mutation may have been of maternal origin, possibly related to antenatal ZDV exposure.
HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya.
Abstract: Eight (8) patients had NRTI resistance mutations with NAMS M184V (54.2%) and K65R (8.4%) mutations being the highest followed by TAMs T215Y and K70R (12.5%).
Result: Of the 6 patients who harboured TAMs mutations, only 3 of them had T215Y mutations while 3 had K70R mutations among those who were on or on a previous AZT treatment.
Table: K70R
Use of dolutegravir in two INI-experienced patients with multiclass resistance resulted in excellent virological and immunological responses.
PMID: 25397500
2014
Journal of the International AIDS Society
Table: K70R
Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.
PMID: 25397495
2014
Journal of the International AIDS Society
Abstract: However, thymidine analogue resistance mutations (TAMs) determined two distinct genotypic profiles in the HIV-1 reverse transcriptase: TAM1: M41L, L210W and T215Y, and TAM2: D67N, K70R, K219E/Q, and T215F.
The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.
Introduction: Several mutations (the thymidine analog mutations, TAM) are required for high-level AZT resistance by excision, and include M41L, D67N, K70R, T215F or Y and K219E or Q.
Introduction: Two of the canonical TAM mutations, K70R and T215Y, form a new ATP binding pocket, which is not present in the wild-type enzyme.
HIV mutation literature information.
PMID: 
2015
BMC infectious diseases
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