Human immunodeficiency virus type 1 drug resistance in a subset of mothers and their infants receiving antiretroviral treatment in Ouagadougou, Burkina Faso.
PMID: 30079168
2018
Journal of public health in Africa
Abstract: Other mutations such as T215F/Y, D67N/E, K70R, and K219Q were associated with intermediate resistance to TDF, AZT, and 3TC.
Result: Also, other DRM such as K70R (5.56%), K219Q (5.56%), T69D (5.56%), Y115F (5.56%) and K65R (5.56%) were detected with equal rates in mothers and were associated with resistance to (AZT, 3TC, TDF), 3TC, DDI, ABC and 3TC respectively.
Discussion: Others mutations detected such as T215F/Y, D67N/E, K70R, and K219Q are associated with intermediate resistance to TDF, AZT, and 3TC.
The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.
Introduction: Moreover, we found that nine amino acid substitutions, namely, M41L, D67Delta, T69G, K70R, L74I, V75T, M184V, T215F, and K219Q (in HIV-1EFdAR), were associated with EFdA resistance.
Result: <
Result: Next, we examined the activity of these compounds against an HIV-1 clone namely HIV-167-75,184,215, harboring seven mutations, D67Delta T69G, K70R, L74I, V75T, M184V, and T215F, derived from HIV-1EFdAR and obtained almost similar results as those obtained for HIV-1EFdAR (Table S2, right column).
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.
Abstract: Thymidine Analogue Mutations (TAMs) such as M41 L, K70R and T215Y were found in all the groups; the most common of the TAMs found were M41 L and T215Y.
Discussion: Generally, it is known that mutations selected by TAMS confer resistance to internationally approved NRTIs; examples of such TAMS encountered in the study are M41 L, D67N, K70R, L210 W, T215Y/F and K219Q/E.
Discussion: However, in the other mothers in this group, M184 V occurred with Thymidine Analogue-Associated Mutations ( PMID: 30408827
2018
PloS one
Result: Less frequently observed were the mutations D67N (n = 8), K65R (n = 2) and K70R (n = 2).
Result: The M184V, K70R and K65R mutations induce high level resistance to NRTIs in recommended first-line regimen according to EACS (9.0).
Discussion: So far, resistance mutations selected by tenofovir and emtricitabine (K65R, K70R and M184V) have been rare (below 1%).
Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.
Result: TAM (M41 L, K70R, L210 W, and Discussion: TDF was used in the second-line program; the mutations associated with resistance to TDF were K65R, TAM (M41 L, K70R, L210 W, T215F), D67N, K70E, and Y115F.
Discussion: The K65R mutation causes intermediate/high-level resistance to TDF; use of TAMs (M41 L, K70R, L210 W, T215F) can reduce TDF susceptibility and cause intermediate/low level resistance to TDF.
The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations.
Abstract: In particular, A62V was observed in various multi-dideoxynucleoside resistant (MDR) mutation complexes, including the Q151M complex (i.e., A62V, V75I, F77L, F116Y, and Q151M), and the T69SSS insertion complex, which has a serine-serine insertion between amino acid positions 69 and 70 (i.e., M41L, A62V, T69SSS, K70R, and T215Y).
Introduction: In particular, A62V is normally seen in different mutational arrangements, located mostly on the flexible beta3-beta4 loop region of the fingers sub-domain of
Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report.
Introduction: In four of the five prior published cases of HIV acquisition despite high PrEP adherence, the virus demonstrated an M184V mutation in reverse transcriptase (RT) conferring resistance to FTC, and three of these viruses also had resistance mutations conferring reduced susceptibility to TDF (K70R or K65R) (Table 1).
Molecular Antiretroviral Resistance Markers of Human Immunodeficiency Virus-1 of CRF01_AE Subtype in Bali, Indonesia.
Discussion: There are two clusters of TAMs; cluster 1 includes substitutions of M41L, L210W and T215Y, while cluster 2 of D67N, K70R, T125F and K219Q/E/N.
HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study.
Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.
Abstract: Overall, 32% (37/116) patients presented >= one major drug resistant mutation(s), with 29% (34/116) to nucleos(t)ide reverse transcriptase inhibitors (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] Result: Out of the 43 sequences generated, the most prevalent DRMs were: (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] K219E/N/Q and 5% [2/43] A62V, followed by other DRMs observed at low rates.
HIV mutation literature information.
PMID: 
2018
Journal of public health in Africa
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