HIV mutation literature information.


  Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).
 PMID: 2479983       1989       Science (New York, N.Y.)
Abstract: Comparative nucleotide sequence analysis of the reverse transcriptase (RT) coding region from five pairs of sensitive and resistant isolates identified three predicted amino acid substitutions common to all the resistant strains (Asp67----Asn, Lys70----Arg, Thr215----Phe or Tyr) plus a fourth in three isolates (Lys219----Gln).



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