literature

HIV mutation literature information.

Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China.

PMID: 32183889 2020 Virology journal

Table: K70R/E

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

PMID: 32105319 2020 The Journal of antimicrobial chemotherapy

Table: K70E

Natural polymorphisms in HIV-1 CRF01_AE strain and profile of acquired drug resistance mutations in a long-term combination treatment cohort in northeastern China.

PMID: 32102660 2020 BMC infectious diseases

Result: The NRTI-associated DRMs detected at TF time point in descending order included K65R (57.1%), M184 V/I (47.6%), S68G (26.2%), A62V (14.3%), K70E/R (9.5%), and Y115F (9.5%).

High resistance to reverse transcriptase inhibitors among persons infected with human immunodeficiency virus type 1 subtype circulating recombinant form 02_AG in Ghana and on antiretroviral therapy.

PMID: 32049783 2020 Medicine

Abstract: Major nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, M184I/V, D67N, T215F, and K70R/E were found.

Discussion: Other mutations detected in this study, which have been shown to confer resistance to NRTIs, were M184I, T69N, L74I, M41L, K70R/E, T215Y/F, and K219E.

Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017).

PMID: 31922125 2020 EClinicalMedicine

Table: K70R/E

Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.

PMID: 31774913 2020 The Journal of infectious diseases

Result: Many of these mutations have previously been associated with drug resistance to tenofovir, either directly (K65R, K70E) or as compensatory mutations for K65R (A62V, S68N, F155Y).

[Prevalence of transmitted drug resistance in HIV-infected treatment-naive patients in Chile].

PMID: 33844760 2020 Revista medica de Chile

Abstract: The mutations in reverse transcriptase were M41L, L210W, D67N, K70E, M184V, K103N (6.36%, 95% CI 3.5-10.4), G190A, E138A, K101E, and I84V in protease.

Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern Tanzania.

PMID: 32986709 2020 PloS one

Table: K70E

Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.

PMID: 33654530 2020 The Pan African medical journal

Table: K70E

Discussion: Our findings reveal major mutations conferring resistance to NRTIs with M184V, Y115F, K65R, D67N, K70E being prevalent.

Survey of Pretreatment HIV Drug Resistance and Genetic Transmission Network Analysis Among HIV Patients in a High Drug-Use Area of Southwest China.

PMID: 31778107 2019 Current HIV research

Result: Thirty-one NRTI mutations were identified, of which the most common were M184L/V (9.1%) and K70R/E (9.1%).