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 HIV mutation literature information.


  Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY(R) System.
 PMID: 27092551       2016       PloS one
Table: K70E


  Treatment failure and drug resistance in HIV-positive patients on tenofovir-based first-line antiretroviral therapy in western Kenya.
 PMID: 27231099       2016       Journal of the International AIDS Society
Result: TDF-associated K70E was found in 3/35 (9%) patients, none with TAMs.
Table: K70E


  Adherence to Pre-Exposure Prophylaxis for HIV Prevention in a Clinical Setting.
 PMID: 27333000       2016       PloS one
Method: Detection and quantification of drug resistance mutations M184V, K70E and K65R when present as minor variants was performed using allele-specific PCR as described elsewhere.


  Genotypic HIV-1 Drug Resistance Among Patients Failing Tenofovir-Based First-Line HAART in South India.
 PMID: 27334566       2016       AIDS research and human retroviruses
Abstract: Mutational association shows, K65R was negatively associated with TAMs (OR 0.31, p .008), M184V (OR 0.14, p .57), and K70E (OR 0.29, p .02).


  HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.
 PMID: 27736898       2016       PloS one
Result: Similarly, within NRTI SDRMs, K70ER, V75A, F77L, M184I, T215I, and K219E were only found under the 5% threshold, while D67G and M184V, although present in levels >=5% in some patients, were also mostly present as low-abundance variants <5% (0.8% vs.


  Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single- or dual-agent preexposure prophylaxis.
 PMID: 25587020       2015       The Journal of infectious diseases
Abstract: METHODS: Within the largest randomized trial of FTC/TDF versus TDF as PrEP, plasma samples were tested for HIV with resistance mutations associated with FTC (K65R and M184IV) and TDF (K65R and K70E), using 454 sequencing.


  High prevalence of the K65R mutation in HIV-1 subtype C infected patients failing tenofovir-based first-line regimens in South Africa.
 PMID: 25659108       2015       PloS one
Result: The K70E mutation, which is known to be selected under TDF pressure, was present in 10 (12.5%) of the TDF-exposed patients as compared to only two (2.5%) of the d4T-exposed patients (not significant).
Table: K70E


  Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
 PMID: 25849352       2015       PLoS medicine
Result: K70E (2.7%; eight of 298) accounted for a higher proportion of the NRTI SDRMs in SSA than in other regions (<0.3% in each of the other regions; p < 0.001).


  Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
 PMID: 26010948       2015       PloS one
Table: K70E


  Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.
 PMID: 26355575       2015       AIDS (London, England)
Result: For NRTIs, K219N and T215rev were consistently above, whereas K70E, M184I/V, L210W and T215Y/F were below the CI.
Discussion: We show here that D30N, N88D/S and L90 M also have high transmissibility and that other SDRMs have higher (M41L, T215Rev and K219E/N/Q/R for NRTIs and K101E/P for the NNRTIs) or lower transmissibility (K70E/R, L74I/V, and



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