literature

HIV mutation literature information.

Evaluation of WHO immunologic criteria for treatment failure: implications for detection of virologic failure, evolution of drug resistance and choice of second-line therapy in India.

PMID: 23735817 2013 Journal of the International AIDS Society

Method: Nucleoside reverse transcriptase inhibitor (NRTI) mutations included in this analysis were as follows: M184V, M184I and M184V/I for lamivudine (3TC) and emtricitabine (FTC) resistance; K65R and K70E, associated with tenofovir (TDF) resistance; thymidine analogue mutations (TAMs) M41L, D67N, K70R, L210W, T215Y, T215F, K219Q, and K219 E, associated with resistance to multiple NRTIs; and multinucleoside mutations, including the

Resistance to tenofovir-based regimens during treatment failure of subtype C HIV-1 in South Africa.

PMID: 23751421 2013 Antiviral therapy

Introduction: In order to further examine the selection of K65R in a subtype C population, we described HIV drug resistance, including the prevalence of minority K65R, K70E, and M184V species, and associations with resistance, including prior receipt of either d4T or zidovudine (AZT), among patients at the time of virological failure on a TDF-containing ART regimen.

Method: Subtype C allele-specific PCR (AS-PCR) assays were used to detect low-level K65R, K70E, and M184V mutations.

Method: The delta cycle thresholds (DeltaCT) and the mutation frequenc

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

PMID: 23840622 2013 PloS one

Abstract: Compared with 720 recipients of a d4T or AZT-containing first-line regimen, the 153 recipients of a TDF-containing first-line regimen were more likely to have the

Result: K70EG occurred in a higher proportion of patients receiving TDF compared to patients receiving d4T or AZT.

Result: K70QEG occurred in 12/153 (7.8%) patients receiving TDF compared with 3/720(0.4%) receiving d4T or AZT (p<0.001).

Persistence of HIV-1 transmitted drug resistance mutations.

PMID: 23904291 2013 The Journal of infectious diseases

Table: K70E

Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana.

PMID: 24119088 2013 BMC infectious diseases

Table: K70E

HIV-1 subtype D infections among Caucasians from Northwestern Poland--phylogenetic and clinical analysis.

PMID: 22359615 2012 PloS one

Table: K70E

Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia.

PMID: 22729198 2012 The Brazilian journal of infectious diseases

Abstract: The most prevalent RT mutations were T215F/V/Y (66.7%), D67G/N (55.6%), K219Q/E/R (44.4%), M184V/I (38.9%), K70R/E (27.8%) and M41L (27.8%), associated with nucleoside reverse transcriptase inhibitors (NRTI) resistance; and K103N (55.6%), G190A (33.3%), and K101P/E/H (27.8%) associated with non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance.

High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen.

PMID: 22739389 2012 AIDS (London, England)

Discussion: Of concern, HIV-1 from approximately 20% of patients in areas in which subtype C is endemic carries the K65R mutation, the K70E mutation, or both after experiencing VF of a d4T- or ddI-based ART regimen.

Virological failure rates and HIV-1 drug resistance patterns in patients on first-line antiretroviral treatment in semirural and rural Gabon.

PMID: 23199801 2012 Journal of the International AIDS Society

Result: No patient displayed viruses harbouring the K65R or K70E mutation selected by TDF.

Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.

PMID: 23305651 2012 Journal of the International AIDS Society

Abstract: K70E and >=3 TAMs were found in 0.015% (95% CI: 0.004 to 0.04) and 0

Result: All 20 sequences with K65R had intermediate or high-level predicted resistance to tenofovir and the three sequences with K70E had low-level predicted tenofovir resistance.

Result: In addition to K65R, other transmitted tenofovir-associated resistance mutations included K70E, seen in three subtype B sequences (0.015%, 95% CI: 0.004 to 0.04) and three or more TAMs (inclusive of either M41L or L210W) seen in 54/19,823 sequences (0.27%, 95% CI: 0.2 to 0.4), the majority of which (46/54) were subtype B sequences.

Browser Board

Co-occurred Entities

Filtrator