HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa.
PMID: 28129253
2017
Journal of acquired immune deficiency syndromes (1999)
Result: After adjustment, participants on zidovudine at failure were more likely to have T215F, T215Y, M41L, K70R, D67N, L210W, type-1 thymidine analog, type-2 thymidine analog, and any thymidine analogue mutations (TAMs); those on tenofovir to have K65R, K70E, Y115F, and M184I; those on efavirenz to have K103N, P225H, Y188L, and L100I; and those on nevirapine to have Y181C and G190A.
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.
Result: K65R was negatively correlated with both K70Q and K70E.
Result: Of the 83 TRAMs, 16 (21%; 16/83) were established NRTI-associated resistance mutations including A62V, K65R/N, T69deletion, K70E/Q/T/N, L74V/I, V75M/I/L, Y115F, and M184V/I and 40 (48%; 40/83) were established NNRTI-associated resistance mutations.
Result: The most notable findings among the NRTI-associated TRAMs were an increased proportion of K65R, S68N<
Drug resistance mutation profiles of the drug-naive and first-line regimen-treated HIV-1-infected population of Suzhou, China.
Abstract: Only L76V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors.
Abstract: Six transmitted drug-resistant mutations were found, including two mutations (L33F and L76V) in the protease region and four (K70N/E and V179D/E) in the RT region.
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Result: A direct robust interaction was observed between treatment experience (eRT) and known NRTI-elicited mutations M184I/V and K70E/R.
Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.
PMID: 28799325
2017
Journal of the International AIDS Society
Result: The NRTI TDRM identified at low frequency by NGS (<10% of the viral population), were D67N, K65R, and K70E, as well as F77L, which was the most frequent (8 patient samples) low-abundance (1.5-5%) NRTI TDRM identified.
Table: K70E
Adherence to Pre-Exposure Prophylaxis for HIV Prevention in a Clinical Setting.
Method: Detection and quantification of drug resistance mutations M184V, K70E and K65R when present as minor variants was performed using allele-specific PCR as described elsewhere.
Genotypic HIV-1 Drug Resistance Among Patients Failing Tenofovir-Based First-Line HAART in South India.
PMID: 27334566
2016
AIDS research and human retroviruses
Abstract: Mutational association shows, K65R was negatively associated with TAMs (OR 0.31, p .008), M184V (OR 0.14, p .57), and K70E (OR 0.29, p .02).
HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.
Result: Similarly, within NRTI SDRMs, K70ER, V75A, F77L, M184I, T215I, and K219E were only found under the 5% threshold, while D67G and M184V, although present in levels >=5% in some patients, were also mostly present as low-abundance variants <5% (0.8% vs.
HIV mutation literature information.
PMID: 
2017
Journal of acquired immune deficiency syndromes (1999)
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