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 HIV mutation literature information.


  Co-evolution of compensatory mutation K43E with mutation M41L in long-term HIV antiretroviral treatment.
 PMID: 18271957       2008       Retrovirology
Result: These assays did not reveal any effect of the K43E change in the wild type or the M41L+T215Y background.
Result: This may indicate that in the absence of the positive effect of the K43E change on RC, the virus can improve its RC by removal of the E40F change.
Result: To better understand the role of the E40F and K43E substitutions we analyzed the frequencies of these substitutions in the Quest Diagnostics reference laboratory database containing more than 160,000 (RT) sequences from patients across the United States (1/1/1999-12/31/2005).


  HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
 PMID: 17500586       2007       PLoS computational biology
Method: NRTI-selected mutations included T39A, M41L, K43E/Q/N, E44D/A, A62V, K65R, D67N/G/E, T69D/N/S/insertion, Method: Recently described accessory NRTI mutations included T39A, K43E/Q/N, E44D/A, V118I, E203K, H208, D218E, H221Y, K223Q, and L228H/R.


  Impact of unreported HIV-1 reverse transcriptase mutations on phenotypic resistance to nucleoside and non-nucleoside inhibitors.
 PMID: 16299731       2006       Journal of medical virology
Abstract: A correlation was found between K20R and lamivudine resistance (P = 0.006) while T39A (P = 0.005), K43EQN (<0.001), E203KD (P = 0.010), and H208Y (P = < 0.001) seemed to be associated with a previous use of zidovudine and stavudine and with the development of thymidine analog resistance.
Abstract: The mutations involving 10 of these positions were associated with a reduced susceptibility to antiretroviral drugs; K20R, T39A, K43EQN, E203KD, H208Y, and D218E were correlated with NRTI resistance while mutations  PMID: 16809324       2006       Journal of virology
Abstract: In particular, T39A, K43E/Q, K122E, E203K, and H208Y clustered with the nucleoside analogue mutation 1 cluster (NAM1; M41L+L210W+T215Y).
Abstract: Moreover, treatment failure in the presence of K43E, K122E, or H208Y was significantly associated with higher viremia and lower CD4 cell count.


  Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.
 PMID: 11920313       2002       The Journal of infectious diseases
Abstract: As expected, E44A/D and V118I mutations were strongly associated with M41L, D67N, L210W, and T215Y but also with other mutations, including K43E/N/Q, T69D, V75M, H208Y, R211K, and K219R.



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