Identification and characterization of HLA-A*0301 epitopes in HIV-1 gag proteins using a novel approach.
PMID: 19903485
2010
Journal of immunological methods
Abstract: Five of the seven peptides that bound to A*0301 contained the K403R mutation and corresponded to the documented LARNCRAPRK-A3 supertype epitope.
Abstract: Using this approach we identified/confirmed the predicted HLA-A*0301 epitopes in two regions of gag containing PS mutations V7I and K403R, one previously reported and the other novel.
Introductio
Introduction: Our previous study of HIV-1 gag in a large HIV-1-infected cohort (N=431) identified three positively selected (PS) amino acids, V7I and I34L in the p17 region of gag (unpublished) and K403R in the p7 region of gag.