Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.
Introduction: Unlike HIV-1, HIV-2 does not develop resistance to nucleoside RT inhibitors (NRTIs) through the excision pathway (involving amino acid substitutions M41L, D67N, K70R, L210W, T215F/Y and K219E/Q in the viral RT), but relies exclusively on nucleotide discrimination.
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.
Method: Because of the possibility that some individuals may have received a thymidine analog before receiving a TDF-containing regimen, as such switches may not have always reported, we excluded from our analysis individuals with sequences containing one or more canonical thymidine analogue mutations (TAMs) - M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E.
Etravirine combined with antiretrovirals other than darunavir/ritonavir for HIV-1-infected, treatment-experienced adults: Week 48 results of a phase IV trial.
Abstract: The proportion of DRM in RNA and DNA were mostly similar with the exception of the thymidine analogue mutations (TAMs) D67N, K70R, K219QE; and K103N which were slightly more prevalent in DNA than RNA.
Result: Interestingly, four DRM were detected in a greater proportion of the population using the DNA assay, of which three were TAMs; namely D67N, K70R and K219Q/R/E.
Result: More than half of these mutations (K65R, D67N, K70R, L74V, V75I/S, Y115F, K219Q/E,
Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.
Abstract: Overall, 32% (37/116) patients presented >= one major drug resistant mutation(s), with 29% (34/116) to nucleos(t)ide reverse transcriptase inhibitors (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] Result: Out of the 43 sequences generated, the most prevalent DRMs were: (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] K219E/N/Q and 5% [2/43] A62V, followed by other DRMs observed at low rates.
Use of Proviral DNA to Investigate Virus Resistance Mutations in HIV-infected Zimbabweans.
Result: The mutations observed were; NRTI mutations T69D, T69N, V75I and M184V; NNRTI mutations, K103N, V106M, Y181C and G190A; and TAMs (M41L, D67N, K70R, L210W, T215Y, K219Q) (Table 3).
Discussion: In this study, TAMs observed were M41L, D67N, K70R, L210W, T215Y<
Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Discussion: In addition to the resistance mutations to NRTIs (M184V and the TAM T215F) and NNRTIs (L100I, Y181C, K103N, V108I, and Y188L) observed in naive subjects, these subjects on ART also had the TAMs D67N, K70R, and K219Q; and 9 of those 11 subjects had major resistance mutations to both NRTIs and NNRTIs.
Discussion: The TAMs T215F
Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.
Result: Among the two TAMs pathways, TAM-2 which features D67N, K70R, T215F, and K219E/Q mutations was more common than the TAM-1 which features M41L, L210W and T215Y.
Table: K219Q
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Method: Primary NRTI-R substitutions assessed were M41L, A62V, K65R, D67N, T69 insertions, K70E/R, L74I/V, V75I, F77L, Y115F, F116Y, Q151M, M184V/I, L210W, T215F/Y, and K219E/N/Q/R in RT.
Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
PMID: 26483513
2016
The Journal of antimicrobial chemotherapy
Abstract: BACKGROUND: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain.
HIV mutation literature information.
PMID: 
2017
Scientific reports
Browser Board
Co-occurred Entities
Filtrator
ViMRT