Abstract: The most prevalent_Nucleoside_Reverse Transcriptase Inhibitor (NRTI) mutations were_M184V/I_(67.3%),_K219/Q/E_(22.6%) and_K65R_(21.1%).
Impact of the M184V/I Mutation on the Efficacy of Abacavir/Lamivudine/Dolutegravir Therapy in HIV Treatment-Experienced Patients.
PMID: 31660328
2019
Open forum infectious diseases
Method: Information on thymidine analogue mutations (TAMs; M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E) before the switch to ABC/3TC/DTG also was obtained.
Result: Among the 21 patients who experienced VF, 2 had 3 archived TAMs (D67N, K70R, and K219Q/E and M41L, K70R, and K219Q/E), including the M184V/I mutation.
Result: One patient had 2 TAMs (D67N and K219Q/E) without an archived M184V/I
Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.
PMID: 31430369
2019
The Journal of antimicrobial chemotherapy
Method: Primary NRTI-R substitutions were M41L, K65R/E/N, D67N, T69 insertions, K70E/R, L74V/I, Y115F, Q151M, M184V/I, L210W, T215Y/F and K219E/Q/N/R in RT.
Result: Pre-existing NRTI-R substitutions were observed in 16% (89/543) of BIC/FTC/TAF-treated participants; the most frequently detected substitutions were Table: K219E/N
Table: K219E/Q
Distinct Pattern of Thymidine Analogue Mutations with K65R in Patients Failing Tenofovir-Based Antiretroviral Therapy.
PMID: 29084434
2018
AIDS research and human retroviruses
Abstract: These were exclusively K219E +- D67N and were not predicted to confer a resistance cost to future AZT-containing regimens.
Introduction: Based on significant previous research of DRMs, TAMs have been described to associate into one of two distinct pathways: TAM-1 (M41L, L210W, T215Y) or TAM-2 (D67N, K70R, T215F, K219E/Q).
Introduction: For all TAMs, with the exception of K219E, D67N, and K70R, there was no acquisition from S1 to S2 in patients on TDF, whereas the mean acquisition rates of individual TAMs in the patients on AZT varied from 0.005 mutation
Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial.
Abstract: At 48 weeks, the nucleoside reverse transcriptase inhibitor (NRTI) mutation
Result: The NRTI mutation K219E/Q (p = 0.004) and the NNRTI mutations K101E/P (p = 0.03) and P225H (p = 0.007) were less common in raltegravir-intensified ART, with no evidence of differences for other mutations (p > 0.1, S8 Fig).
Discussion: Despite similar rates of virological failure >=1,000 copies/mL, raltegravir-intensified ART was associated with lower rates of the NRTI mutation K219E/Q and the NNRTI mutations K101E/P and P225H.
Prevalence of M184V and K65R in proviral DNA from PBMCs in HIV-infected youths with lamivudine/emtricitabine exposure.
PMID: 29084434
2018
AIDS research and human retroviruses
Introduction: However, three males in the study exhibited the K65R, K219E +- D67N pattern.
Introduction: In comparing the observed versus expected frequencies of individual mutations, K219E was 26% more likely to appear with K65R than expected in both S1 and S2 samples in patients on TDF.
Introduction: In the 56 patients with K65R present at S2, none of the TAMs (K219E +- D67N) were predicted to cause resistance to the AZT component of a potential 2L regimen.
Introduction: In viruses lacking K65R, the TAMs observed included a broader array of primarily TAM-2, including K219E, D67N, PMID: 29617912
2018
Clinical infectious diseases
Result: Given the high frequency of M184V/I detected in all samples (28%, 56/197), these mutations were combined with thymidine-analog mutations (TAMs; ie, M41L, L210W, T215Y, D67N, K70R, T215F, K219Q/E) for analysis.
Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data.
Discussion: Generally, it is known that mutations selected by TAMS confer resistance to internationally approved NRTIs; examples of such TAMS encountered in the study are M41 L, D67N, K70R, L210 W, T215Y/F and K219Q/E.
Discussion: However, in the other mothers in this group, M184 V occurred with Thymidine Analogue-Associated Mutations (K70R, K219E, M41 LM and T215I); it therefore produced a synergistic effect that led to different levels of reduction in susceptibility.
Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.
HIV mutation literature information.
PMID: 
2019
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