Discussion: A high frequency of minor PI resistance mutations (M36I, L63P, and K20R/I) has been reported in newly diagnosed immigrants from Spain, infected with non-B subtypes.
The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?
Result: When we used the best subset selector, LSE estimates of the coefficients and 10-fold CV to identify our model potentially leading to a novel LPV/r score, besides pre-TCE viral load, 5 mutations
Table: K20I
Discussion: In addition, we identified previously unrecognized mutations I62V ad K20I, which appear to have a modest impact in reducing viral response, and mutations I15V and V91S which, in contrast, seem to determine LPV/r hypersensitivity, all of which need further investigation.
Discussion: Mutations K20I and I54V were given smaller weights in our score which is consistent with the fact that are not major IAS-USA mutations but are listed in most available IS (I54V is not included in ANRS).
Prevalence and resistance mutations of non-B HIV-1 subtypes among immigrants in Southern Spain along the decade 2000-2010.
Abstract: Patients infected with non-B subtypes showed a high frequency of minor protease inhibitor resistance mutations, M36I, L63P, and K20R/I.
Result: The M36I mutation in protease was observed in all patients, whilst K20I/R, L63P, V77I and L10V/I
Discussion: Our results indicated that patients infected with HIV-1 non-B subtypes showed a high frequency of minor PR mutations (polymorphisms) as M36I, L63P, and K20R/I, in contrast to the low proportion of major resistance mutations.
HIV drug resistance surveillance using pooled pyrosequencing.
Abstract: Subtype specific secondary polymorphisms such as K20I and M36I in the PR were observed in almost all patients.
Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients.
PMID: 19147519
2009
The Journal of antimicrobial chemotherapy
Abstract: Cochran-Armitage procedure identified eight mutations with a negative impact on the virological response, namely K14R, K20I, E34Q, I47V, I54M, K55R, T74P and I84V; and two mutations (E35D and V82A) with a positive impact.
Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure.
PMID: 18992847
2009
Infection, genetics and evolution
Table: K20I
Discussion: The mutations L10F/R, K20I, V32I, I47V/A, I50L/V, I54L/A/M/T/S, A71T, G73C/T/A, V77I, and V82F/T/S, either absent or observed in our subtype B and F1 viruses, were not statistically different in viruses isolated from treated or untreated patients.
Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon.
PMID: 18507527
2008
AIDS research and human retroviruses
Abstract: Other mutations frequently detected were K20I, L63P, H69K, and I13V.
HIV mutation literature information.
PMID: 
2013
Journal of medical virology
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