literature

HIV mutation literature information.

High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014.

PMID: 30640198 2019 The Pediatric infectious disease journal

Abstract: The most frequent mutations were K103N/S (48.0%), M184V (37.5%), G190A/S (15.1%), and Y181C/G/V (14.1%).

Result: The most frequent mutations observed were K103N/S (48.0%), M184V (37.5%), G190A/S/E/Q/R (15.1%), and Y181C/G/V (13.8%) (Table 1).

Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.

PMID: 30650082 2019 PloS one

Result: The most common TDRMs found in baseline samples were the T215 revertants, followed by E138A/G/K/Q/R, K103NS, V179DE and M41L (S1 Table).

Trends in HIV-1 Drug Resistance Mutations from a U.S. Reference Laboratory from 2006 to 2017.

PMID: 31169022 2019 AIDS research and human retroviruses

Abstract: K103N/S/T declined from 42.5% in 2012 to 36.4% in 2017.

Delayed linkage to HIV care among asylum seekers in Quebec, Canada.

PMID: 31842822 2019 BMC public health

Result: Baseline resistance to at least one NNRTI was the most commonly ob

Discussion: In fact, among the seven newly diagnosed individuals with a K103 N/S mutation, three were women with living children, suggesting that prior exposure to nevirapine for MTCT may have been possible.

Discussion: That said, the frequency of K103 N/S resistance mutations among treatment-experienced patients was identical to provincial data (17%).

HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review.

PMID: 31745412 2019 Oman medical journal

Abstract: M184V/I, K103N/S, and G190A/S/E were the most common mutations detected.

Result: The most common mutations were M184V/I (45; 53.6%), K103N/S (41; 48.8%), and G190A/S/E (20; 23.8%).

Discussion: M184V/I, K103N/S, and G190A/S/E were the most common mutations detected among those patients.

Molecular Genetics and the Incidence of Transmitted Drug Resistance Among Pre-Treatment HIV-1 Infected Patients in the Eastern Cape, South Africa.

PMID: 31584370 2019 Current HIV research

Abstract: K103N/S, V106M and M184V were the most common mutations identified among the viral sequences.

Rates of HIV-1 virological suppression and patterns of acquired drug resistance among fisherfolk on first-line antiretroviral therapy in Uganda.

PMID: 31257432 2019 The Journal of antimicrobial chemotherapy

Discussion: All individuals with ADR had NNRTI mutations with K103N/S, Y181C, K101E/Q and G190S/A being more prevalent, depicting extensive use of the NNRTIs nevirapine and efavirenz in first-line regimens in this setting.

Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.

PMID: 31430369 2019 The Journal of antimicrobial chemotherapy

Method: Primary NNRTI-R substitutions were L100I, K101E/P,

Result: NNRTI-R substitutions were observed in 23% (124/543) of participants; the most frequently detected substitutions were K103N/S in 12% (64/543) and rilpivirine-associated resistance substitutions (L100I, K101E/P, E138A/G/K/Q/R, V179L, Y181C/I/V, Y188L, H221Y, F227C or M320I/L) in 10% (53/543) (Table 3).

Table: K103N/S

HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting.

PMID: 31117863 2019 Journal of the International Association of Providers of AIDS Care

Table: K103S

Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.

PMID: 30442114 2018 BMC infectious diseases

Table: K103S

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