Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania.
PMID: 35107140
2022
The Journal of antimicrobial chemotherapy
Abstract: Common mutations in RT were M184V (75%), T215Y (41.1%), K103N (39.3%), M41L (32.1%), D67DN (30.3%), G190A (28.6%) and A98G (26.8%).
Table: K103N
Discussion: Some of the most common mutations in this study were M184V, K103N, Y181C and G190A, which occurred at similar frequencies to those reported in studies from other SSA and Tanzanian settings.
Magnetic Bead Processing Enables Sensitive Ligation-Based Detection of HIV Drug Resistance Mutations.
Abstract: In studies with synthesized nucleic acids based on the well-studied HIV mutation, K103N, the assay successfully differentiated between wild-type and mutant for RNA targets with high specificity.
Prevalence of HIV-1 drug resistance in Eastern European and Central Asian countries.
Abstract: Additionally, the K103N/S mutation was mainly observed in clustered sequences (6.2% vs 2.8%).
Discussion: Notably, K103N/S, which was previously described as DRM with transmission fitness similar to wild-type virus with the ability to persist for years in the infected host, was found mainly in clustered sequences (6.2%) then outside clusters (2.8%).
Discussion: The predominant NNRTI DRMs included E138A/G, which is the natural polymorphic mutation for sub-subtype A6, was previously shown to have a prevalence of 7% frequency in Russian HIV-infected patients, and is associated with low-level DR to rilpivirine, which is not taken into account in the assessment of PDR; V106I, which alone causes a minimal reduction in
Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.
PMID: 35061384
2022
Journal of medicinal chemistry
Abstract: Especially, for the changeling mutations F227L/V106A and K103N/Y181C, both compounds exhibited remarkably improved activity compared to those of etravirine and rilpivirine.
Prevalence of transmitted drug resistance among ART-naive HIV-infected individuals, Beijing, 2015-2018.
PMID: 35092830
2022
Journal of global antimicrobial resistance
Abstract: K103N/KN (NNRTI associated) and M46L/I/IMV/IM/ML (protease inhibitor associated) were the other major resistance mutations.
Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase.
Introduction: K103N/ Y181C double mutations were associated with resistance to EFV and NVP NNRTI inhibitors.
Introduction: A high prevalence of NNRTIs drug mutations was found in K103N, V106M, Y181C, and G190A.
Introduction: This research aimed to isolate potential specific anti-HIV-1 RT DNA aptamers again
Introduction: informed that the mutation of K103N was detected in patients on efavirenz (EFV) more than nevirapine (NVP) treatment.
Introduction: reported NVP induced K103N, Y181C, and G190A mutations.
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.
PMID: 33567378
2021
European journal of medicinal chemistry
Abstract: Compounds 16a1 and 16b1 turned out to be the most potent inhibitors against WT and mutant HIV-1 strains (L100I, K103N, and E138K), with EC50 values ranging from 0.007 muM to 0.043 muM.
Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.
Abstract: Y181C is selected in patients receiving nevirapine, etravirine and rilpivirine, and together with K103N is the most prevalent NNRTI-associated mutation in HIV-infected patients.
HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.
Result: The major NNRTI DRMs were V179D/E (37.9%, 149/393), V106I/M (25.7%, 101/393), and K103N/Q (25.2%, 99/393) (Table 3).
Table: K103N/Q
Discussion: V106I/M, K103N/Q, G190A/S, and Y181C were the major NNRTI-associated mutations, similar to those in other cities in China and other countries, and showed broad-spectrum resistance possibly caused by the wide use of NNRTIs.
Prevalence of transmitted HIV-1 drug resistance among treatment-naive individuals in China, 2000-2016.
HIV mutation literature information.
PMID: 
2022
The Journal of antimicrobial chemotherapy
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