Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory-based phenotypes among CRF01_AE and subtype B HIV-infected individuals.
Result: Among the 37 screen failures, the most common reason for failure was presence of an exclusionary RAM at screening (n = 19; most common were K103N [5] and V179E/I/V [4]).
Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia.
Abstract: The most common NRTI mutations were M184V (80%), L74V (31%), L74I (17%), K219E (9%), and M184I (9%), NNRTI mutations were K103N (83%), P225H (14%), L100I (11%), and Y188L (11%), reflecting generally the similar pattern of DRMs to that seen in treatment failed subtype B viruses.
Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651.
Abstract: The newly synthesized non-nucleosides were tested for antiviral activity against wild type HIV-1 IIIB as well as the resistant strains N119 (Y181C), A17 (K103N+Y181C), and the triple mutant EFV(R) (K103R+V179D+P225H) in MT-4 cells.
Patterns of HIV-1 Drug-Resistance Mutations among Patients Failing First-Line Antiretroviral Treatment in South India.
PMID: 26385878
2016
Journal of the International Association of Providers of AIDS Care
Abstract: RESULTS: Of the study patients followed up for 6 months, 23 patients failed first-line therapy and the mutation of I135R/T/V/X, L178 I/M, M184V/I, D67N, K70R, and K103N was most common.
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
PMID: 26414663
2016
AIDS research and human retroviruses
Abstract: Nonnucleoside reverse transcriptase inhibitor-associated TDRMs were detected in 3.3% (44/1,306) of patients (L100I, K101E/P, K103N/S, V179F, Y188H/L/M, Y181I/C, and G190A/E/S) and TDRMs to protease inhibitors were detected in 2.3% (30/1,306) of patients (M46L, I50V, I54V, Q58E, L76V, V82A/C/L/T, N83D, I84V, and L90M
Characteristics of Transmitted Drug-Resistant HIV-1 in Recently Infected Treatment-Naive Patients in Japan.
PMID: 26428230
2016
Journal of acquired immune deficiency syndromes (1999)
Abstract: Furthermore, sequences with these mutations, K103N and D30N/N88D formed clusters on phylogenetic trees.
Prevalence of transmitted HIV-1 drug resistance among young adults attending HIV counselling and testing clinics in Kigali, Rwanda.
Abstract: Two participants (4%) had the K103N non-nucleoside reverse transcriptase inhibitor (NNRTI) mutation and one (2%) had the M46L protease inhibitor (PI) mutation.
HIV-1 Genetic Diversity and Transmitted Drug Resistance in Antiretroviral Treatment-Naive Individuals from Amapa State, Northern Brazil.
PMID: 26529282
2016
AIDS research and human retroviruses
Abstract: Only one TDRM (K103N) was detected in a single patient from our study population.
CD4 count-based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone.
PMID: 26584666
2016
Tropical medicine & international health
Result: The median time from ART initiation to resistance testing was 17 months (IQR: 10, 29) and the median time from first HIV RNA >1000 copies/mL to resistance testing was 0 months (IQR: 0, 3.3); 308 (88%) of HIV drug resistance tests came from the first visit with an HIV RNA >1000 copies/mL; 151 (43%) had the M184V mutation while 220 (63%) had any NNRTI resistance, 117 (33%) of whom had the K103N mutation; 14 (4%) had thymidine analogue mutations (TAMs).
HIV mutation literature information.
PMID: 
2016
Journal of medical virology
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