Near Full-Length Genomic Characterization of a Novel HIV-1 B/C Recombinant Form Identified in Guangdong Province, China.
PMID: 33287631
2021
AIDS research and human retroviruses
Abstract: In addition, this B/C recombinant strain contained the non-nucleoside reverse transcriptase inhibitor resistance mutation K103N and the integrase strand transfer inhibitor other resistance mutation L74I according to the Stanford University HIV Drug Resistance Database program.
First Assessment of Acquired HIV-1 Drug Resistance and Mutation Patterns in Suriname.
PMID: 33287618
2021
AIDS research and human retroviruses
Abstract: The most common DRMs were M184V (23.6%) and K103N (18.8%).
Determination of reverse transcriptase inhibitor resistance mutations in HIV-1 infected children in Cote d'Ivoire.
Result: Four SDRMs increased in prevalence in RTI-naive persons including K103N, V106M, and G190A/E while L100I decreased in prevalence among RTI-naive persons.
Result: The SDRMs with the lowest treated/naive prevalence ratios were G190E (11-fold) and K103N (22-fold).
Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.
PMID: 34069929
2021
International journal of molecular sciences
Result: K103N remained stable in the studied period.
Result: Similarly, all the other 10 most frequent SDRM followed a decreasing trend along the years with the remarkable exception for K65R and K103N (Figure 1).
Result: The most common SDRM (Figure 1, Supplementary Table S2) were the substitutions in RT amino acids M184V (65.53%, n = 13,265), K103N (40.20%, n = 8738), and M41L (17.21%, n = 3480).
Result: While the prevalence of viruses harboring K103N increased between 2014 (40.97%, n = 1180) and 2015 (47.12%, n = 1293; p < 0.001) this was accompanied with a significant decrease in 2016 (42.53%, n = 2145; p < 0.001) and no significant difference between 2008 and 2017 (p = 0.919).
Discussion:
Surveillance of Pretreatment Drug Resistance Among HIV-Infected Children in Ibadan, Nigeria.
PMID: 34074135
2021
AIDS research and human retroviruses
Abstract: Three out of the four mutations were identified as non-nucleoside reverse transcriptase inhibitors DRM (K103N), whereas the fourth had nucleoside reverse transcriptase inhibitors DRM (M184V).
Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina.
PMID: 34085506
2021
Revista espanola de quimioterapia
Abstract: Predominant NNRTI RAMs were K103N (n=4; 10%) and G190A/E/S (n=3; 7.5%).
Re
Discussion: K103N, most frequent NNRTI RAM, has a fitness similar to wild-type virus, a property that justifies its predominance within viral quasispecies population.
Discussion: A notable exception to this are mutations located in G190 position: G190S and G190A both have reduced replication efficiency relative to wild-type and K103N-mutants.
Discussion: Regarding overall prevalence of transmitted drug resistance, RAMs to NNRTI were predominant (mostly K103N) as in our original study and most Latin American reports.
Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.
Abstract: Interestingly, few compounds displayed remarkable activity in inhibiting K103N mutant virus with EC50 values ranging from 39 nM to 1.708 microM.
Abstract: Notably, FS2 (EC50(IIIB) = 16 nM, EC50(K103N) = 39 nM, SI = 294) was identified as the most significant compound, which was considerably more potent than nevirapine, lamivudine, and comparable to zidovudine.
In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations.
PMID: 32974670
2021
The Journal of antimicrobial chemotherapy
Abstract: As expected, single NNRTI mutations K103N and Y181C did not impair doravirine susceptibility (FC 1.4 and 1.8, respectively), while reduced activity was observed with the single M230L or double K103N/Y181C mutations (FC 7.6 and 4.9, respectively).
Abstract: METHODS: In vitro phenotypic susceptibility to doravirine was assessed in 10 clinically derived infectious clones with intermediate- to high-level resistance to rilpivirine, etravirine, efavirenz and nevirapine, and in NL4-3 site-directed mutants harbouring K103N, Y181C, M230L or K103N/Y181C NNRTI m
Prevalence and factors associated with HIV-1 drug resistance mutations in treatment-experienced patients in Nairobi, Kenya: A cross-sectional study.
Abstract: NRTI primary mutations M184 V/I and K65R/E/N were found in 28.8% and 8.9% of subjects respectively, while NNRTI primary mutations K103N/S, G190A, and Y181C were found in 21.0%, 14.6%, and 10.9% of subjects.
HIV mutation literature information.
PMID: 
2021
AIDS research and human retroviruses
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