Prevalence of drug resistance among HIV-1 treatment-naive patients in Greece during 2003-2015: Transmitted drug resistance is due to onward transmissions.
PMID: 28688977
2017
Infection, genetics and evolution
Abstract: For subtype B, 68.1% (139 out of 204) of resistant strains (E138A, K103N, E138Q V179D) belonged to clusters.
Abstract: The majority of subtype A sequences (89.7%; 245 out of 273) with the dominant NNRTI resistance mutations (E138A, K103N, E138Q, V179D) were found to belong to monophyletic clusters suggesting regional dispersal.
Abstract: The most frequently observed NNRTI resistant mutations were E138A (7.7%), E138Q (4.0%), K103N (2.3%) and V179D (1.3%).
HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China.
Abstract: M184V was the most frequently found point mutation, conferring resistance to the nucleoside reverse transcriptase inhibitor, while Y181C, G190A, K103N and V179D/E/F were the most frequent point mutations conferring resistance to the non-nucleoside reverse transcriptase inhibitor.
Result: We found that M184V was the most frequent point mutation conferring resistance against NRTIs, whereas Y181C, G190A, K103N and V179D/E/F were the most frequent point mutations conferring resistance to PMID: 28750647
2017
AIDS research and therapy
Abstract: The most common DRMs were; M184V (51.7%), K103N (50%), V106M (20.6%), D67N (13.3%), K65R (12%).
Abstract: The proportion of DRM in RNA and DNA were mostly similar with the exception of the thymidine analogue mutations (TAMs) D67N, K70R,
Table: K103N
Discussion: The high occurrence of both K103N and V106M could be a reflection of the wide use of EFV and NVP as part of the first line therapy.
Discussion: The use of nevirapine monotherapy could have potentially impacted on the observed level of NNRTI mutations particularly K103N.
HIV Resistance and Prevention of Mother-to-Child Transmission Regimen in HIV-Infected Infants in Northern Tanzania.
PMID: 28797181
2017
AIDS research and human retroviruses
Abstract: The most common HLRMs to NVP were K103 N, Y181C, and Y188 L.
Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.
PMID: 28799325
2017
Journal of the International AIDS Society
Abstract: The most abundant, albeit, minor-frequency RT TDRM, were the K65R and D67N, while K103N, M184V and T215S were high-frequency mutations.
Discussion: K103N is considered to have a limited effect on viral fitness and, therefore, can be continuously transmitted as a major mutation that dominates the viral pool and impacts future therapy.
Discussion: The high frequency (>20% of the viral population) NRTI M184V and T215S and NNRTI K103N mutations identified here in several cases, have already been reported to be primarily confined to recently ide
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Abstract: We report covalent inhibitors of Tyr181Cys RT (CRTIs) that can completely knock out activity of the resistant mutant and of the particularly challenging Lys103Asn/Tyr181Cys variant.
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Abstract: A62V, V90I, K103N, or E138A/G/K/Q; 68-82%) demonstrated virologic suppression at week 48, with no resistance development except for one patient with M184V and pre-existing K103N in the ATV + RTV + FTC/TDF group.
Community Based Antiretroviral Treatment in Rural Zimbabwe.
PMID: 28899102
2017
AIDS research and human retroviruses
Abstract: Seven participants had sequence data available, and five had drug resistance mutations, K65R, T69N, K101E, K103N, Y181C/I, M184V, and G190A.
Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa.
PMID: 28981637
2017
The Journal of antimicrobial chemotherapy
Abstract: DRMs were detected in 89% of 123 specimens with VF, including M184I/V, K103N/S, K65N/R, V106A/M and Y181C.
Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.
PMID: 29026792
2017
Iranian journal of public health
Abstract: The analysis of reverse transcriptase showed M184V (68.9%), T215YISF (44.8%), K103N (27.6%) and the analysis results of protease revealed G73SC (13.8%) and I47VA (6.9%).
Result: The most common mutation seen for the NRTIs was M184V and for the NNRTIs was K103N.
Table: K103N
Discussion: For NNRTIs the most common mutated sequence was reported to be K103N that is similar to the findings of other studies.
HIV mutation literature information.
PMID: 
2017
Infection, genetics and evolution
Browser Board
Co-occurred Entities
Filtrator
ViMRT