literature

HIV mutation literature information.

[Genetic analysis of the mutations in HIV-1 infected population in Ecuador].

PMID: 29652972 2018 Revista chilena de infectologia

Abstract: Results The most frequent mutations were M184V/I, K101E/P/H, K103N/S, D30N, M46L/I, I54L/M, V82T/F/A/S/L and L90M in adults and F77L, K103N/S, M46L/I, V82T/F/A/S/L and L90M in children.

Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data.

PMID: 29661246 2018 AIDS research and therapy

Result: Only 3% of patients showed no other mutation, and the most common associated major reverse transcriptase mutations were M184V (47%), K103N (35%) and K65R (29%).

"Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the ""NNRTI Adjacent"" Binding Site."

PMID: 29670696 2018 ACS medicinal chemistry letters

Abstract: Especially, 20 showed marked antiviral activity, which was 1.5-fold greater against WT and 1.5- to 3-fold greater against L100I, K103N, Y181C, Y188L, and E138K when compared with ETV.

A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients.

PMID: 29683855 2018 AIDS (London, England)

Result: This patient harbored a K103N mutation at screening, indicating transmitted NNRTI (efavirenz and nevirapine) resistance.

Discussion: Only one patient (D/C/F/TAF) was found to have M184I/V, conferring resistance to emtricitabine; this patient also had a transmitted K103N mutation at screening.

Seroconversion on preexposure prophylaxis: a case report with segmental hair analysis for timed adherence determination.

PMID: 29683856 2018 AIDS (London, England)

Abstract: On day 2, HIV-1 RNA was 27 316 copies/ml, genotyping revealed M184V, K70T, K65R, and K103N mutations, plasma TFV and FTC concentrations were consistent with recent dosing.

Introduction: In that case, if the patient was not fully adherent to PrEP when exposed to HIV in the past, the patient could have developed the NRTI-resistant mutations (M184V, K70T, and K65R) through the selective pressure of FTC/TDF prophylaxis after acquiring a virus carrying the K103N mutation.

Introduction: On day 2, his HIV-1 RNA was 27 316 copies/ml, and genotyping (by population sequencing) subsequently revealed significant mutations in the reverse transcr

HIV-1 transmission networks across Cyprus (2010-2012).

PMID: 29684083 2018 PloS one

Abstract: There were only three newly diagnosed patients with transmitted drug resistant HIV-1 strains, one study subject from the United Kingdom infected with subtype B strain and one from Romania with sub-subtype A2 strain, both with PI drug resistance mutation M46L and one from Greece with sub-subtype A1 with non-nucleoside reverse transcriptase inhibitors (NNRTI) drug resistance mutation K103N.

Result: Specifically, there was one patient (CY369) infected with an HIV-1 strain with a non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation (K103N) and two patients (CY274 and CY314) with a protease

Table: K103N

HIV-1 transmitted drug resistance in Slovenia and its impact on predicted treatment effectiveness: 2011-2016 update.

PMID: 29698470 2018 PloS one

Abstract: K103N was detected in two patients and T68D and T215D in one person each, corresponding to a prevalence of 0%, 1.2%, and 1.2% of TDR to protease inhibitors (PIs),

Result: SDRMs were only found in four individuals (2.4%); namely, mutation K103N in two patients and T68D and T215D in one each.

Result: The first sequence is part of the largest Slovenian cluster (n = 53) and carries the T69D mutation, the second sequence is within a cluster of 20 Slovenian sequences and carries M46I, and the third is in a phylogenetic relationship with two other Slovenian sequences and is carries K103N (Fig 2).

Changes from 2000 to 2009 in the Prevalence of HIV-1 Containing Drug Resistance-Associated Mutations from Antiretroviral Therapy-Naive, HIV-1-Infected Patients in the United States.

PMID: 29732898 2018 AIDS research and human retroviruses

Result: Analysis of the three most prevalent NNRTI mutations is shown in Figure 6; the prevalence of the K103N/S mutation continued to increase until 2008 (6% in 2008) and then declined in prevalence in 2009 to 3%.

Result: The most prevalent NNRTI mutation was K103N/S with 4%, 95% CI: 3.7%-5.0%.

Result: The prevalence of NNRTI mutations was 6% [95% CI (5.5%-7.0%)], and t

Appearance of Drug Resistance Mutations Among the Dominant HIV-1 Subtype, CRF01_AE in Maumere, Indonesia.

PMID: 29732988 2018 Current HIV research

Abstract: The major drug resistance-associated mutations, M184V, K103N, Y188L, and M230I, were found in the RT genes.

High prevalence of HIV-1 transmitted drug resistance among therapy-naive Burmese entering travelers at Dehong ports in Yunnan, China.

PMID: 29739342 2018 BMC infectious diseases

Result: For NNRTI resistance-associated mutations, V179D/T was identified as the major mutation (20 cases), and the other 6 types of mutation were E138A, A98G, K101P, K103 N, Y181H and Y188H.

Discussion: The major TDRMs observed in this study have been reported in a previous study of HIV Drug Resistance among ART-failure individuals in Yunnan Province, which figured out mutations such as M184 V/I, K103 N, V106A, Y181C and G190A were common.

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