literature

HIV mutation literature information.

Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/AIDS in a Minority Area, China.

PMID: 34708015 2021 Frontiers in public health

Result: As for the NNRTI resistance, the majority of the HIV-1 strains showed high-level resistance to NVP (3.95%) and EFV (3.64%), and the main mutation was K103N/KN (data not shown).

Result: Besides, 37.38% (40/107) of individuals carrying TDR were involved in the network, and K103N (42.5%, 17/40) was the most frequent TDR-associated mutation, followed by E138A (15%, 6/40), I54M (7.5%, 3/40), and Discussion: K103N (42.5%, 17/40) were the most frequent TDR-associated mutations and were in five clusters in which they linked with those carrying the same mutations.

Human Immunodeficiency Virus (HIV) Drug Resistance, Phylogenetic Analysis, and Superinfection Among Men Who Have Sex with Men and Transgender Women in Sub-Saharan Africa: HIV Prevention Trials Network (HPTN) 075 Study.

PMID: 32761071 2021 Clinical infectious diseases

Abstract: Major drug resistance mutations were detected in samples from 21 (14.6%) of 144 participants; the most frequent mutations were K103N and M184V/I.

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

PMID: 34762770 2021 Journal of the International AIDS Society

Abstract: Overall, 18/168 (11%) had NNRTI mutations including K101E

Result: Major NNRTI mutations detected included K101E, K103N, K103S, V106M, V108I, E138A/G, V179D/I/T and H221Y, but the frequency of detection of each of these mutations did not differ by arm (Table 1).

Result: Of these six, only one participant from the placebo arm had an NNRTI resistance mutation detected (K103N) in a sample collected 8 weeks after cessation of the placebo ring.

Near Real-Time Identification of Recent Human Immunodeficiency Virus Transmissions, Transmitted Drug Resistance Mutations, and Transmission Networks by Multiplexed Primer ID-Next-Generation Sequencing in North Carolina.

PMID: 32663847 2021 The Journal of infectious diseases

Abstract: The reverse-transcriptase region K103N was the most commonly detected DRM (prevalence, approximately 15%).

Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia.

PMID: 34819737 2021 Infection and drug resistance

Abstract: Among NRTI resistance mutations, M184V (73.2%), K219Q (63.4%) and T215 (56.1%) complex were the most mutated positions, while the most common NNRTI resistance mutations were K103N (24.4%), K101E, P225H and V108I 7.5% each.

Result: Of the 41 viraemic specimens genotyped, the major NNRTI resistance-associated mutations detected were: K103N (24.4%), P225H (7.3%), K101E (7.3%), V108I (7.3%), V90I (4.9%), V106M/A (9.8%),

PMID: 35069498 2021 Frontiers in microbiology

Result: All individuals in two of the CRF07_BC clusters carried Q58E (PI mutations, N = 29) and 52.6% (10/19) in the other CRF07_BC clusters carried K103N (NNRTI mutations).

Result: Of all clusters, 96.4% (53/55) of individuals with TDR mutation in these clusters were MSM and only two (in clusters with M46L and K103N) were infected through heterosexual transmission (HST) (Figure 4).

Result: Transmitted drug resistance mutations detected in more than 10 cases included PI [Q58E (n = 51) and M46ILV (n = 46)] and NNRTI [K103N (n = 26), E138AGKQ

HIV Pretreatment Drug Resistance Trends in Mexico City, 2017-2020.

PMID: 34959542 2021 Pathogens (Basel, Switzerland)

Result: Other interesting clusters evidencing PDR transmission within the network included cluster PI-1, with 29 nodes, all men with PI resistance and median age 24 (22-28) enrolled across all years; cluster NRTI-1, with 23 nodes, 22 cisgender men and 1 cisgender woman, with median age 22 (10-27) and constant growth across all years; cluster complex-1, with 10 nodes, all men enrolled from 2018 to 2020 and median age 23 (20-30), 60% (6/10) with PI + NRTI + NNRTI resistance and 40% (4/10) with PI + NRTI resistance; and complex-2, with 7 nodes, all men with median age 26 (21-31) sharing PR M46I, L90M,

First Assessment of Acquired HIV-1 Drug Resistance and Mutation Patterns in Suriname.

PMID: 33287618 2021 AIDS research and human retroviruses

Abstract: The most common DRMs were M184V (23.6%) and K103N (18.8%).

Application of Molecular Docking for the Development of Improved HIV-1 Reverse Transcriptase Inhibitors.

PMID: 32598265 2021 Current computer-aided drug design

Abstract: Here, protein-ligand interactions and possible binding modes of novel compounds with the HIV-1 RT binding pocket (the wild-type as well as Y181C and K103N mutants) were obtained and discussed.

[HIV-1 drug resistance and subtypes in newly reported HIV/AIDS patients before antiretroviral therapy in Taizhou city, 2016-2018].

PMID: 34814456 2021 Zhonghua liu xing bing xue za zhi

Abstract: The resistance mutations of NNRTIs and NRTIs were mainly K103 N (0.7%) and M184I/V (0.5%).

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