literature

HIV mutation literature information.

Sexual intermingling of Arab and Jewish MSM in Israel: results of a molecular epidemiology study.

PMID: 30325775 2019 AIDS (London, England)

Abstract: Overall, 13.1% (66/502) had TDRM; reverse transcriptase-K103N/S, M184 V, T215S and protease-L90M were the most common.

Abstract: Phylogenetic analysis demonstrated AMSM and JMSM clusters including L90M, K103N/S or T215S TDRM.

Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.

PMID: 30380053 2019 The Journal of antimicrobial chemotherapy

Result: Among all DRM20% detected in ART-initiator participants (n = 148), 137/148 (92.6%) belonged to the NNRTI class, mostly represented by the K103N/S mutations (n = 88/137, 64.2%), while 11/148 (7.4%) were NRTI mutations (Figure 1a).

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.

PMID: 30381875 2019 Chemical biology & drug design

Abstract: Especially, against the mutant strains K103N and E138K, most compounds exhibited more potent activity than against WT HIV-1.

Moderate-to-High Levels of Pretreatment HIV Drug Resistance in KwaZulu-Natal Province, South Africa.

PMID: 30430843 2019 AIDS research and human retroviruses

Abstract: The most prevalent SDRMs were K103NS (7.5%), M184VI (2.4%), and V106AM (1.4%).

Torsional flexibility of undecorated catechol diether compound as potent NNRTI targeting HIV-1 reverse transcriptase.

PMID: 30445408 2019 Journal of molecular graphics & modelling

Abstract: In this study, torsional flexibility of an undecorated catechol diether compound in the binding pocket of wild type and mutants (Y181C and K103N/Y181C) HIV-1 RT is investigated by using QM/MM calculations.

Rare occurrence of doravirine resistance-associated mutations in HIV-1-infected treatment-naive patients.

PMID: 30476106 2019 The Journal of antimicrobial chemotherapy

Abstract: Overall, the presence of at least one doravirine resistance-associated mutation (n = 137; 1.4%) or the K103N/Y181C mutations (n = 5; 0.05%) was very rare.

Abstract: We studied the prevalence of doravirine resistance-associated mutations previously identified in vitro: V106A/M, V108I, Y188L, V190S, H221Y, F227C/L/V, M230I/L, L234I, P236L, Y318F and K103N/Y181C.

Effect of alpha-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones.

PMID: 30525601 2019 Journal of medicinal chemistry

1Abstract: The various alpha-methoxy DABO series (12-14) present different SAR at the dihalo benzyl substitution, with the most potent compounds (12d,e and 13c) showing similar (picomolar/nanomolar) anti-HIV-1 potency as the corresponding alpha-methyl analogues against wt HIV-1, and 10-100-fold increased potency (up to low nanomolar) against clinically relevant K103N, Y181C, Y188L, IRLL98, and K103N+Y181C HIV-1 mutant strains, highlighting the importance of the alpha-methoxy substitution to provide highly efficient DABOs as ""second generation"" NNRTIs."

Virological outcomes of boosted protease inhibitor-based first-line ART in subjects harbouring thymidine analogue-associated mutations as the sole form of transmitted drug resistance.

PMID: 30544247 2019 The Journal of antimicrobial chemotherapy

Method: The remaining 311 (4.5%) subjects were excluded owing to the presence of other forms of TDR, most commonly the NNRTI mutation K103N.

Pretreatment HIV Drug Resistance and Virologic Outcomes to First-Line Antiretroviral Therapy in Peru.

PMID: 30560685 2019 AIDS research and human retroviruses

Abstract: Blood specimens from ARV-naive individuals were assessed for PDR to NNRTI-based ART by an oligonucleotide ligation assay (OLA) sensitive to 2% mutant within an individual's HIV quasispecies at reverse transcriptase codons M41L, K65R, K103N, Y181C, M184V, and G190A, and by Sanger consensus sequencing (CS).

Prevalence of HIV-1 transmitted drug resistance and viral suppression among recently diagnosed adults in Sao Paulo, Brazil.

PMID: 30569276 2019 Archives of virology

Abstract: One or more TDR (based on the WHO surveillance list) was observed in 10.9% (CI 95%, 8.6-13.6) of the sequences, the most common of which was the K103 N mutation, which confers resistance to first-generation drugs of the non-nucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral drug class.

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