literature

HIV mutation literature information.

HIV Pretreatment Drug Resistance Trends in Mexico City, 2017-2020.

PMID: 34959542 2021 Pathogens (Basel, Switzerland)

Result: Other interesting clusters evidencing PDR transmission within the network included cluster PI-1, with 29 nodes, all men with PI resistance and median age 24 (22-28) enrolled across all years; cluster NRTI-1, with 23 nodes, 22 cisgender men and 1 cisgender woman, with median age 22 (10-27) and constant growth across all years; cluster complex-1, with 10 nodes, all men enrolled from 2018 to 2020 and median age 23 (20-30), 60% (6/10) with PI + NRTI + NNRTI resistance and 40% (4/10) with PI + NRTI resistance; and complex-2, with 7 nodes, all men with median age 26 (21-31) sharing PR M46I, L90M,

Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/AIDS in a Minority Area, China.

PMID: 34708015 2021 Frontiers in public health

Result: As for the NNRTI resistance, the majority of the HIV-1 strains showed high-level resistance to NVP (3.95%) and EFV (3.64%), and the main mutation was K103N/KN (data not shown).

Result: Besides, 37.38% (40/107) of individuals carrying TDR were involved in the network, and K103N (42.5%, 17/40) was the most frequent TDR-associated mutation, followed by E138A (15%, 6/40), I54M (7.5%, 3/40), and Discussion: K103N (42.5%, 17/40) were the most frequent TDR-associated mutations and were in five clusters in which they linked with those carrying the same mutations.

Molecular Network Analysis Reveals Transmission of HIV-1 Drug-Resistant Strains Among Newly Diagnosed HIV-1 Infections in a Moderately HIV Endemic City in China.

PMID: 35069498 2021 Frontiers in microbiology

Result: All individuals in two of the CRF07_BC clusters carried Q58E (PI mutations, N = 29) and 52.6% (10/19) in the other CRF07_BC clusters carried K103N (NNRTI mutations).

Result: Of all clusters, 96.4% (53/55) of individuals with TDR mutation in these clusters were MSM and only two (in clusters with M46L and K103N) were infected through heterosexual transmission (HST) (Figure 4).

Result: Transmitted drug resistance mutations detected in more than 10 cases included PI [Q58E (n = 51) and M46ILV (n = 46)] and NNRTI [K103N (n = 26), E138AGKQ

Prevalence of Antiretroviral Drug Resistance Mutations Among Pretreatment and Antiretroviral Therapy-Failure HIV Patients in Uzbekistan.

PMID: 32873061 2021 AIDS research and human retroviruses

Abstract: ART-naive cohort I (PDR) included six samples that contained at least one surveillance drug resistance mutation (SDRM) (2.96%), with the most common being K103N mutation (4/6).

Abstract: In ART-experienced patients, cohort II, 77.4% (82/106) of viruses contained at least one mutation against PIs, NRTIs, or NNRTIs, with the most common mutations of M184V/I (49.1%; 52/106), K65R (18.9%; 20/106), K103N (23.6%; 25/106), and G190S (22.6%; 24/106).

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

PMID: 34762770 2021 Journal of the International AIDS Society

Abstract: Overall, 18/168 (11%) had NNRTI mutations including K101E

Result: Major NNRTI mutations detected included K101E, K103N, K103S, V106M, V108I, E138A/G, V179D/I/T and H221Y, but the frequency of detection of each of these mutations did not differ by arm (Table 1).

Result: Of these six, only one participant from the placebo arm had an NNRTI resistance mutation detected (K103N) in a sample collected 8 weeks after cessation of the placebo ring.

[HIV-1 drug resistance and subtypes in newly reported HIV/AIDS patients before antiretroviral therapy in Taizhou city, 2016-2018].

PMID: 34814456 2021 Zhonghua liu xing bing xue za zhi

Abstract: The resistance mutations of NNRTIs and NRTIs were mainly K103 N (0.7%) and M184I/V (0.5%).

Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia.

PMID: 34819737 2021 Infection and drug resistance

Abstract: Among NRTI resistance mutations, M184V (73.2%), K219Q (63.4%) and T215 (56.1%) complex were the most mutated positions, while the most common NNRTI resistance mutations were K103N (24.4%), K101E, P225H and V108I 7.5% each.

Result: Of the 41 viraemic specimens genotyped, the major NNRTI resistance-associated mutations detected were: K103N (24.4%), P225H (7.3%), K101E (7.3%), V108I (7.3%), V90I (4.9%), V106M/A (9.8%),

PMID: 32663847 2021 The Journal of infectious diseases

Abstract: The reverse-transcriptase region K103N was the most commonly detected DRM (prevalence, approximately 15%).

In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations.

PMID: 32974670 2021 The Journal of antimicrobial chemotherapy

Abstract: As expected, single NNRTI mutations K103N and Y181C did not impair doravirine susceptibility (FC 1.4 and 1.8, respectively), while reduced activity was observed with the single M230L or double K103N/Y181C mutations (FC 7.6 and 4.9, respectively).

Abstract: METHODS: In vitro phenotypic susceptibility to doravirine was assessed in 10 clinically derived infectious clones with intermediate- to high-level resistance to rilpivirine, etravirine, efavirenz and nevirapine, and in NL4-3 site-directed mutants harbouring K103N, Y181C, M230L or K103N/Y181C NNRTI m

Application of Molecular Docking for the Development of Improved HIV-1 Reverse Transcriptase Inhibitors.

PMID: 32598265 2021 Current computer-aided drug design

Abstract: Here, protein-ligand interactions and possible binding modes of novel compounds with the HIV-1 RT binding pocket (the wild-type as well as Y181C and K103N mutants) were obtained and discussed.

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