literature

HIV mutation literature information.

Surveillance of Pretreatment Drug Resistance Among HIV-Infected Children in Ibadan, Nigeria.

PMID: 34074135 2021 AIDS research and human retroviruses

Abstract: Three out of the four mutations were identified as non-nucleoside reverse transcriptase inhibitors DRM (K103N), whereas the fourth had nucleoside reverse transcriptase inhibitors DRM (M184V).

Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.

PMID: 34069929 2021 International journal of molecular sciences

Result: K103N remained stable in the studied period.

Result: Similarly, all the other 10 most frequent SDRM followed a decreasing trend along the years with the remarkable exception for K65R and K103N (Figure 1).

Result: The most common SDRM (Figure 1, Supplementary Table S2) were the substitutions in RT amino acids M184V (65.53%, n = 13,265), K103N (40.20%, n = 8738), and M41L (17.21%, n = 3480).

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Result: Four SDRMs increased in prevalence in RTI-naive persons including K103N, V106M, and G190A/E while L100I decreased in prevalence among RTI-naive persons.

Result: The SDRMs with the lowest treated/naive prevalence ratios were G190E (11-fold) and K103N (22-fold).

Determination of reverse transcriptase inhibitor resistance mutations in HIV-1 infected children in Cote d'Ivoire.

PMID: 33170745 2021 Genome

Abstract: Frequently encountered resistance mutations were for NRTIs: M184V (88%), TAMs (67%), T215F/I/V/Y (33%), and L74I/V (24%); for NNRTIs: K103N/S (74%), P225H (26%), and G190A/E/Q (24%).

First Assessment of Acquired HIV-1 Drug Resistance and Mutation Patterns in Suriname.

PMID: 33287618 2021 AIDS research and human retroviruses

Abstract: The most common DRMs were M184V (23.6%) and K103N (18.8%).

Near Full-Length Genomic Characterization of a Novel HIV-1 B/C Recombinant Form Identified in Guangdong Province, China.

PMID: 33287631 2021 AIDS research and human retroviruses

Abstract: In addition, this B/C recombinant strain contained the non-nucleoside reverse transcriptase inhibitor resistance mutation K103N and the integrase strand transfer inhibitor other resistance mutation L74I according to the Stanford University HIV Drug Resistance Database program.

High HIV-1 Virological Failure and Drug Resistance among Adult Patients Receiving First-Line ART for At least 12 Months at a Decentralized Urban HIV Clinic Setting in Senegal before the Test-and-Treat.

PMID: 34025122 2021 Infectious diseases

Abstract: Of the 27 viraemic isolates successfully genotyped, 20 (74.1%) carried DR mutations; most frequent were M184VI (55.6%), K103N (37.1%), thymidine analog mutations (29.6%), Y181CY (22.2%).

Tabl

Discussion: EFV and NVP have a lower genetic barrier, thus facilitating the selection of K103N and Y181C mutations.

HIV-1 subtypes and drug resistance in children during antiretroviral therapy in Brazil.

PMID: 33788308 2021 Journal of medical virology

Abstract: The most common primary mutations found were M184V (29.5%), K103N (25%), M41L (9.8%), T215Y (8.3%), and G190A (8.3%).

HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.

PMID: 33557775 2021 BMC infectious diseases

Discussion: High-level resistance to efavirenz and nevirapine primarily resulted from the mutations K103N, L100I, and P225H.

Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.

PMID: 33567378 2021 European journal of medicinal chemistry

Abstract: Compounds 16a1 and 16b1 turned out to be the most potent inhibitors against WT and mutant HIV-1 strains (L100I, K103N, and E138K), with EC50 values ranging from 0.007 muM to 0.043 muM.

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