Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa.
Abstract: The most frequent non-nucleoside reverse transcriptase inhibitor (NNRTI) RAM was K103N/S (40/96, 42%).
Result: We observed that the K103N/S mutation occurred in 41 (43%) of those patients failing cART.
Table: K103N/S
Discussion: The K103N mutation occurred at a higher frequency in patients receiving AZT plus 3TC or ABC plus 3TC than in those receiving TDF plus 3TC, and 3TC plus d4T.
Discussion: The high rate of K103N RAM is also well documented and has been observed in several previous studies.
HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016.
Abstract: The leading DRMs observed in the study were M184I/V (59.59%) against NRTIs and K103N (37.55%) against NNRTIs.
Result: K103N (37.55%, 92/245) was the most frequent mutation, followed by G190A/E/K/Q/S/V (28.57%, 70/245), V179I/D/E/T (27.76%, 68/245), V106A/I/M (26.12%, 64/245), Y181C/V (18.78%, 46/245), K101E/H/P (14.69%, 36/245), Y188C/H/L (5.71%, 14/245), L100I (4.08%, 10/245), and M230L (4.08%, 10/245).
Characteristics of drug resistance in HIV-1 CRF55_01B from ART-experienced patients in Guangdong, China.
PMID: 32300784
2020
The Journal of antimicrobial chemotherapy
Abstract: Among DRMs, M184V (43.83%) was the most frequent NRTI DRM, followed by K65R (23.46%), and V179E (98.77%) was the most frequent NNRTI DRM, followed by K103N (47.53%) and Y181C (14.81%).
HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia.
Discussion: Conversely, G190S development in A6 isolates is significantly higher (up to 30% to 60%) after EFV and/or nevirapine (NVP)-exposure and is favoured over the K103N and Y181C resistance pathways.
Discussion: In non-A6 isolates, K103NRT or Y181CRT are preferentially detected after efavirenz exposure while G190SRT is rarely observed, probably due to high costs in replication capacity (in the subtype B context, 20% compared to the wt).
Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains.
Introduction: Selective acquisition of G190S, which causes higher levels of EFV and NVP resistance than K103N, in HIV-1 subtype A from Russia is another example of a distinct genetic barrier to resistance among different subtypes.
HIV-1 drug resistance mutations detection and HIV-1 subtype G report by using next-generation sequencing platform.
Discussion: Another survey focusing on Burmese individuals staying in Dehong reported that M184V, K103N/KN, and T74S/ST were the major SDRMs associated with VF.
Discussion: Furthermore, we found that the major NNRTI-related SDRMs were K101P, K103N, V106A, E138A, Y181C, and Y188H, and the major NRTI-related SDRMs were L74V/I and M184V.
Discussion: Some SDRMs, including NRTI-related mutations (M41L, D6
HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-naive blood donors in China.
Result: Furthermore, two blood donors with K103N mutation in the reverse transcriptase gene w
Discussion: Drug resistance analysis demonstrated that 2.4% of HIV-1 isolates contained at least one NNRTI (K101E, K103N) or PI (M46I) SDRMs, the overall prevalence of TDR was lower than previous reports in Zhejiang (11.1%) and Shijiazhuang (6.1%) among treatment-naive HIV-infected individuals, but similar to a nationwide cross-sectional survey about prevalence of TDR (3.6%) in 2015 in China.
Discussion: The RT K103N mutation found in two strains can reduce EFV and NVP susceptibility by about 20- and 50-fold, respectively.
The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China.
Abstract: Among the DRMs detected, some independently conferred resistance, such as K65R (1.6%, 5/322), Y188C/F/L (0.9%, 3/322), K103N (0.6%, 2/322) and G190A (0.3%, 1/322), which conferred high-level resistance.
Result: Among the key DRMs for NNRTIs, Y188C/F/L (0.9%, 3/322),
Table: K103N
Discussion: Among the NNRTI resistance mutations in this study, the key mutations were K103N, Y188L and G190A, which usually cause high-level resistance to NNRTIs but whose frequencies were low among the participants.
Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi.
Abstract: The most common mutation was K103N (5.6%, 11/197), followed by Y181C (3.6%, 7/197).
Result: The most common PDR was K103N (5.6%, 11/197), followed by Y181C (3.6%, 7/197).
Table: K103N
Discussion: Among the 12 patients with K103N and/or V106M mutations (leading to a functional dual NRTI-therapy), only four were alive and on ART at the end of follow-up.
HIV mutation literature information.
PMID: 
2020
Frontiers in microbiology
Browser Board
Co-occurred Entities
Filtrator
ViMRT