Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa.
Abstract: Several RTI RAMs, such as K65R, M184V or K103N and PI RAM V82A, were identified in < 20% of the population.
Abstract: The majority of the drug resistance mutations in the minor viral quasispecies were observed in the V82A mutation (n = 13) in protease and K65R (n = 5), K103N (n = 7) and M184V (n = 5) in reverse transcriptase.
Result: Most of the DRMs in the minor viral quasispecies were observed in V82A mutation (n = 13) in protease and K65R (n = 5),
Transmitted drug resistance among HIV-1 drug-naive patients in Greece.
PMID: 33592343
2021
International journal of infectious diseases
Abstract: The most frequent resistance sites were E138A (9.6%), K103N (6.4%), and K101E (2.1%).
Distribution characteristics of drug resistance mutations of HIV CRF01_AE, CRF07_BC and CRF08_BC from patients under ART in Ganzhou, China.
PMID: 34402512
2021
The Journal of antimicrobial chemotherapy
Abstract: The most common DRMs of these three subtypes were K103N and M184V, while the mutation frequencies of M41L, D67N, K70R, K101E, V106M, Y181C, K219E, H221Y and N348I were obviously different among subtypes.
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.
PMID: 33567378
2021
European journal of medicinal chemistry
Abstract: Compounds 16a1 and 16b1 turned out to be the most potent inhibitors against WT and mutant HIV-1 strains (L100I, K103N, and E138K), with EC50 values ranging from 0.007 muM to 0.043 muM.
HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.
Abstract: The most common mutations Y181I/C and K103N, were found in 7 and 9 youths, respectively.
Result: <
Result: K103N and Y181C were the most common TDRMs in NNRTI.
Table: K103N
Discussion: Among these mutations, K103N (n = 9) and Y181C/I (n = 7) were the most common TDRMs.
Discussion: In summary, large sample size and more epidemiological data are required to evaluate the potential role of three classes of TDR (NNRTI/NRTI/PI) or K103N, Y181C in affecting the decline of CD4 count.
Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction.
Introduction: However, nevirapine had no effect on PPT removal in reactions carried out with HIV-1 RT containing the drug resistance-associated substitution K103N.
Discussion: However, doravirine appears to be more efficient than efavirenz and/or rilpivirine in suppressing resistance breakthrough of HIV-1 strains with the common NNRTI resistance-associated mutations such as K103N, Y181C or K103N/Y181C.
Discussion: The effectiveness of doravirine in suppressing transmitted drug resistance mediated by K103N was crucial for its approval.
Discussion: The highest levels of doravirine resistance (fold-change >100) have been associated with amino acid substitutions V106A
"Detection of Drug Resistance Mutations in the Reverse Transcriptase Gene of HIV-1-Infected North Indian Population Failing First-Line Antiretroviral Therapy ""A Follow-Up Cohort Study""."
PMID: 33390085
2021
AIDS research and human retroviruses
Abstract: Drug resistance mutation M184V (ATG to GTA) (63.15%) associated with lamivudine and abacavir and K103N (AAG or AAA to AAU) (36.84%) associated with efavirenz and nevirapine were predominantly identified in first-line ART failure patients.
Transmitted HIV-1 drug resistance in a large international cohort using next-generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study.
Abstract: Using the 2% detection threshold, individual DRMs with the highest prevalence were: PI M46IL (5.5%), RT K103NS (3.5%), RT Discussion: However, mutations like the RT K103NS, the T215 revertants and the PI L90M appear to have little effect on viral fitness and may persist for prolonged periods in individuals with TDR.
Discussion: Of the most frequent NNRTI DRMs, G190ASE occurred predominately as minor variants while K103NS was dominant in the quasispecies.
Molecular Network Analysis Reveals Transmission of HIV-1 Drug-Resistant Strains Among Newly Diagnosed HIV-1 Infections in a Moderately HIV Endemic City in China.
Result: All individuals in two of the CRF07_BC clusters carried Q58E (PI mutations, N = 29) and 52.6% (10/19) in the other CRF07_BC clusters carried K103N (NNRTI mutations).
Result: Of all clusters, 96.4% (53/55) of individuals with TDR mutation in these clusters were MSM and only two (in clusters with M46L and K103N) were infected through heterosexual transmission (HST) (Figure 4).
Result: Transmitted drug resistance mutations detected in more than 10 cases included PI [Q58E (n = 51) and M46ILV (n = 46)] and NNRTI [K103N (n = 26), E138AGKQ
HIV mutation literature information.
PMID: 
2021
BMC infectious diseases
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