literature

HIV mutation literature information.

Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.

PMID: 34069929 2021 International journal of molecular sciences

Result: K103N remained stable in the studied period.

Result: Similarly, all the other 10 most frequent SDRM followed a decreasing trend along the years with the remarkable exception for K65R and K103N (Figure 1).

Result: The most common SDRM (Figure 1, Supplementary Table S2) were the substitutions in RT amino acids M184V (65.53%, n = 13,265), K103N (40.20%, n = 8738), and M41L (17.21%, n = 3480).

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Result: Four SDRMs increased in prevalence in RTI-naive persons including K103N, V106M, and G190A/E while L100I decreased in prevalence among RTI-naive persons.

Result: The SDRMs with the lowest treated/naive prevalence ratios were G190E (11-fold) and K103N (22-fold).

Determination of reverse transcriptase inhibitor resistance mutations in HIV-1 infected children in Cote d'Ivoire.

PMID: 33170745 2021 Genome

Abstract: Frequently encountered resistance mutations were for NRTIs: M184V (88%), TAMs (67%), T215F/I/V/Y (33%), and L74I/V (24%); for NNRTIs: K103N/S (74%), P225H (26%), and G190A/E/Q (24%).

First Assessment of Acquired HIV-1 Drug Resistance and Mutation Patterns in Suriname.

PMID: 33287618 2021 AIDS research and human retroviruses

Abstract: The most common DRMs were M184V (23.6%) and K103N (18.8%).

Near Full-Length Genomic Characterization of a Novel HIV-1 B/C Recombinant Form Identified in Guangdong Province, China.

PMID: 33287631 2021 AIDS research and human retroviruses

Abstract: In addition, this B/C recombinant strain contained the non-nucleoside reverse transcriptase inhibitor resistance mutation K103N and the integrase strand transfer inhibitor other resistance mutation L74I according to the Stanford University HIV Drug Resistance Database program.

Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.

PMID: 33352387 2021 Bioorganic & medicinal chemistry

Abstract: Y181C is selected in patients receiving nevirapine, etravirine and rilpivirine, and together with K103N is the most prevalent NNRTI-associated mutation in HIV-infected patients.

HIV-1 subtypes and drug resistance in children during antiretroviral therapy in Brazil.

PMID: 33788308 2021 Journal of medical virology

Abstract: The most common primary mutations found were M184V (29.5%), K103N (25%), M41L (9.8%), T215Y (8.3%), and G190A (8.3%).

Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.

PMID: 33567378 2021 European journal of medicinal chemistry

Abstract: Compounds 16a1 and 16b1 turned out to be the most potent inhibitors against WT and mutant HIV-1 strains (L100I, K103N, and E138K), with EC50 values ranging from 0.007 muM to 0.043 muM.

Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.

PMID: 33979774 2021 Bioorganic & medicinal chemistry

Abstract: What's more, some compounds also showed low nanomole activity against some mutant strains such as K103N and E138K.

HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.

PMID: 33557775 2021 BMC infectious diseases

Discussion: High-level resistance to efavirenz and nevirapine primarily resulted from the mutations K103N, L100I, and P225H.

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