literature

HIV mutation literature information.

Management of a human immunodeficiency virus case with discordant antiviral drug resistance profiles in cerebrospinal fluid compared with plasma: a case report.

PMID: 35164871 2022 Journal of medical case reports

Conclusion: The HIV-1 pol gene genotypic resistance analysis showed development of the NRTI M184V mutation, and NNRTI K103N and E138EK mutations in plasma, respectively.

Conclusion: The nonpolymorphic NNRTI K103N mutation causes high-level resistance to efavirenz (EFV), and E138K mutation causes potential low-level cross-resistance to EFV, which was discontinued together with 3TC.

Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania.

PMID: 35107140 2022 The Journal of antimicrobial chemotherapy

Abstract: Common mutations in RT were M184V (75%), T215Y (41.1%), K103N (39.3%), M41L (32.1%), D67DN (30.3%), G190A (28.6%) and A98G (26.8%).

Table: K103N

Discussion: Some of the most common mutations in this study were M184V, K103N, Y181C and G190A, which occurred at similar frequencies to those reported in studies from other SSA and Tanzanian settings.

Comparing effectiveness of first-line antiretroviral therapy between peri-urban and rural clinics in KwaZulu-Natal, South Africa.

PMID: 35023287 2022 HIV medicine

Abstract: K103N (59%) and M184V (52%) were the most common mutations, followed by V106M and K65R (31% each).

Magnetic Bead Processing Enables Sensitive Ligation-Based Detection of HIV Drug Resistance Mutations.

PMID: 35077642 2022 Analytical chemistry

Abstract: In studies with synthesized nucleic acids based on the well-studied HIV mutation, K103N, the assay successfully differentiated between wild-type and mutant for RNA targets with high specificity.

Prevalence of transmitted drug resistance among ART-naive HIV-infected individuals, Beijing, 2015-2018.

PMID: 35092830 2022 Journal of global antimicrobial resistance

Abstract: K103N/KN (NNRTI associated) and M46L/I/IMV/IM/ML (protease inhibitor associated) were the other major resistance mutations.

Prevalence of HIV-1 drug resistance in Eastern European and Central Asian countries.

PMID: 35061671 2022 PloS one

Abstract: Additionally, the K103N/S mutation was mainly observed in clustered sequences (6.2% vs 2.8%).

Discussion: Notably, K103N/S, which was previously described as DRM with transmission fitness similar to wild-type virus with the ability to persist for years in the infected host, was found mainly in clustered sequences (6.2%) then outside clusters (2.8%).

Discussion: The predominant NNRTI DRMs included E138A/G, which is the natural polymorphic mutation for sub-subtype A6, was previously shown to have a prevalence of 7% frequency in Russian HIV-infected patients, and is associated with low-level DR to rilpivirine, which is not taken into account in the assessment of PDR; V106I, which alone causes a minimal reduction in

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.

PMID: 34377002 2021 Infection and drug resistance

Result: The major NNRTI DRMs were V179D/E (37.9%, 149/393), V106I/M (25.7%, 101/393), and K103N/Q (25.2%, 99/393) (Table 3).

Table: K103N/Q

Discussion: V106I/M, K103N/Q, G190A/S, and Y181C were the major NNRTI-associated mutations, similar to those in other cities in China and other countries, and showed broad-spectrum resistance possibly caused by the wide use of NNRTIs.

Transmitted HIV-1 drug resistance in a large international cohort using next-generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study.

PMID: 33369017 2021 HIV medicine

Abstract: Using the 2% detection threshold, individual DRMs with the highest prevalence were: PI M46IL (5.5%), RT K103NS (3.5%), RT Discussion: However, mutations like the RT K103NS, the T215 revertants and the PI L90M appear to have little effect on viral fitness and may persist for prolonged periods in individuals with TDR.

Discussion: Of the most frequent NNRTI DRMs, G190ASE occurred predominately as minor variants while K103NS was dominant in the quasispecies.

Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.

PMID: 33567378 2021 European journal of medicinal chemistry

Abstract: Compounds 16a1 and 16b1 turned out to be the most potent inhibitors against WT and mutant HIV-1 strains (L100I, K103N, and E138K), with EC50 values ranging from 0.007 muM to 0.043 muM.

Distribution characteristics of drug resistance mutations of HIV CRF01_AE, CRF07_BC and CRF08_BC from patients under ART in Ganzhou, China.

PMID: 34402512 2021 The Journal of antimicrobial chemotherapy

Abstract: The most common DRMs of these three subtypes were K103N and M184V, while the mutation frequencies of M41L, D67N, K70R, K101E, V106M, Y181C, K219E, H221Y and N348I were obviously different among subtypes.

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