Abstract: Recombinant
RT enzymes and viruses containing
K101E, but not
E138K, were highly resistant to nevirapine (NVP) and delavirdine (DLV) as well as ETR and RPV, but not EFV.
Abstract: Resistance to the recently approved
nonnucleoside reverse transcriptase inhibitor (
NNRTI) rilpivirine (RPV) commonly involves substitutions at positions
E138K and
K101E in HIV-1
reverse transcriptase (
RT), together with an
M184I substitution that is associated with resistance to coutilized emtricitabine (FTC).